Complement activation in amyloid plaques in Alzheimer's dementia - PubMed (original) (raw)
Complement activation in amyloid plaques in Alzheimer's dementia
P Eikelenboom et al. Virchows Arch B Cell Pathol Incl Mol Pathol. 1989.
Abstract
Amyloid plaques in Alzheimer's dementia contain complement factors C1q, C4 and C3. In the present study we demonstrate complement activation in amyloid plaques using immunoenzymatical techniques and specific antibodies against subunits of individual complement components and activated complement products. Amyloid plaques contain C1q and activated C3 fragments (C3c and C3d, g) but no C1s and C3a. These findings demonstrate that the complement components are not passively bound to the amyloid plaque structures but are the result of an activation process. The role of complement activation in the genesis of senile plaques is discussed.
Similar articles
- Cytokines associated with amyloid plaques in Alzheimer's disease brain stimulate human glial and neuronal cell cultures to secrete early complement proteins, but not C1-inhibitor.
Veerhuis R, Janssen I, De Groot CJ, Van Muiswinkel FL, Hack CE, Eikelenboom P. Veerhuis R, et al. Exp Neurol. 1999 Nov;160(1):289-99. doi: 10.1006/exnr.1999.7199. Exp Neurol. 1999. PMID: 10630213 - Immunoglobulins and complement factors in senile plaques. An immunoperoxidase study.
Eikelenboom P, Stam FC. Eikelenboom P, et al. Acta Neuropathol. 1982;57(2-3):239-42. doi: 10.1007/BF00685397. Acta Neuropathol. 1982. PMID: 6812382 - Early complement components in Alzheimer's disease brains.
Veerhuis R, Janssen I, Hack CE, Eikelenboom P. Veerhuis R, et al. Acta Neuropathol. 1996;91(1):53-60. doi: 10.1007/s004019570001. Acta Neuropathol. 1996. PMID: 8773146 - Evolutionary perspectives on amyloid and inflammatory features of Alzheimer disease.
Finch CE, Marchalonis JJ. Finch CE, et al. Neurobiol Aging. 1996 Sep-Oct;17(5):809-15. doi: 10.1016/0197-4580(96)00119-4. Neurobiol Aging. 1996. PMID: 8892356 Review. - Complement activation as a biomarker for Alzheimer's disease.
Aiyaz M, Lupton MK, Proitsi P, Powell JF, Lovestone S. Aiyaz M, et al. Immunobiology. 2012 Feb;217(2):204-15. doi: 10.1016/j.imbio.2011.07.023. Epub 2011 Jul 23. Immunobiology. 2012. PMID: 21856034 Review.
Cited by
- Complement C3aR signaling: Immune and metabolic modulation and its impact on Alzheimer's disease.
Gedam M, Zheng H. Gedam M, et al. Eur J Immunol. 2024 Aug;54(8):e2350815. doi: 10.1002/eji.202350815. Epub 2024 May 22. Eur J Immunol. 2024. PMID: 38778507 Review. - The Importance of Complement-Mediated Immune Signaling in Alzheimer's Disease Pathogenesis.
Batista AF, Khan KA, Papavergi MT, Lemere CA. Batista AF, et al. Int J Mol Sci. 2024 Jan 9;25(2):817. doi: 10.3390/ijms25020817. Int J Mol Sci. 2024. PMID: 38255891 Free PMC article. Review. - CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states.
Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M. Leng K, et al. Nat Neurosci. 2022 Nov;25(11):1528-1542. doi: 10.1038/s41593-022-01180-9. Epub 2022 Oct 27. Nat Neurosci. 2022. PMID: 36303069 Free PMC article. - Unveiling Leukocyte Extracellular Traps in Inflammatory Responses of the Central Nervous System.
Colciaghi F, Costanza M. Colciaghi F, et al. Front Immunol. 2022 Jul 1;13:915392. doi: 10.3389/fimmu.2022.915392. eCollection 2022. Front Immunol. 2022. PMID: 35844591 Free PMC article. Review. - Prostacyclin Promotes Degenerative Pathology in a Model of Alzheimer's Disease.
Womack TR, Vollert CT, Ohia-Nwoko O, Schmitt M, Montazari S, Beckett TL, Mayerich D, Murphy MP, Eriksen JL. Womack TR, et al. Front Cell Neurosci. 2022 Feb 7;16:769347. doi: 10.3389/fncel.2022.769347. eCollection 2022. Front Cell Neurosci. 2022. PMID: 35197825 Free PMC article.
MeSH terms
LinkOut - more resources
Other Literature Sources
Medical
Miscellaneous