Deficient maternal zinc intake-but not folate-is associated with lower fetal heart rate variability - PubMed (original) (raw)

Observational Study

Deficient maternal zinc intake-but not folate-is associated with lower fetal heart rate variability

Marisa N Spann et al. Early Hum Dev. 2015 Mar.

Abstract

Objective: Few studies of maternal prenatal diet and child development examine micronutrient status in relation to fetal assessment.

Methods: Twenty-four-hour dietary recall of zinc and folate and 20min of fetal heart rate were collected from 3rd trimester pregnant adolescents.

Results: Deficient zinc was associated with less fetal heart rate variability. Deficient folate had no associations with HRV. Neither deficient zinc nor deficient folate was related to fetal heart rate.

Conclusions: These findings, from naturalistic observation, are consistent with emerging data on prenatal zinc supplementation using a randomized control design.

Practical implication: Taken together, the findings suggest that maternal prenatal zinc intake is an important and novel factor for understanding child ANS development.

Keywords: Fetal heart rate variability; Folate; Zinc.

Copyright © 2015. Published by Elsevier Ireland Ltd.

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Conflict of interest statement

Conflict of interest statement None.

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References

1. 1. Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr. 2007;85(2):614S–20S. - PubMed
2. 1. Black MM. The evidence linking zinc deficiency with children’s cognitive and motor functioning. J Nutr. 2003;133(5 Suppl. 1):1473S–6S. - PMC - PubMed
3. 1. Schlotz W, Phillips DI. Fetal origins of mental health: evidence and mechanisms. Brain Behav Immun. 2009;23(7):905–16. - PubMed
4. 1. Barker DJ. The Wellcome Foundation Lecture, 1994. The fetal origins of adult disease. Proc R Soc Lond B. 1995;262(1363):37–43. - PubMed
5. 1. Zeisel SH. Is maternal diet supplementation beneficial? Optimal development of infant depends on mother’s diet. Am J Clin Nutr. 2009;89(2):685S–7S. - PMC - PubMed

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