Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review - PubMed (original) (raw)
Review
Interaction of dietary compounds, especially polyphenols, with the intestinal microbiota: a review
Aleksandra Duda-Chodak et al. Eur J Nutr. 2015 Apr.
Abstract
The intestinal microbiome plays an important role in the metabolism of chemical compounds found within food. Bacterial metabolites are different from those that can be generated by human enzymes because bacterial processes occur under anaerobic conditions and are based mainly on reactions of reduction and/or hydrolysis. In most cases, bacterial metabolism reduces the activity of dietary compounds; however, sometimes a specific product of bacterial transformation exhibits enhanced properties. Studies on the metabolism of polyphenols by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review article presents possible pathways of polyphenol metabolism by intestinal bacteria and describes the diet-derived bioactive metabolites produced by gut microbiota, with a particular emphasis on polyphenols and their potential impact on human health. Because the etiology of many diseases is largely correlated with the intestinal microbiome, a balance between the host immune system and the commensal gut microbiota is crucial for maintaining health. Diet-related and age-related changes in the human intestinal microbiome and their consequences are summarized in the paper.
Figures
Fig. 1
Proposed pathways of bacterial metabolism of daidzin and daidzein (based on [16, 103, 111]) (color figure online)
Fig. 2
Ligands for estrogen receptors generated by the intestinal microbiota: a urolithin A; b 8-prenylnaringenin; and c enterolactone and enterodiol (based on 16, 97, 120) (color figure online)
Fig. 3
Possible pathways of the transformation of quercetin and its glycosides due to metabolism by intestinal bacteria (based on [16, 138, 156, 157]) (color figure online)
Similar articles
- Influence of functional food components on gut health.
Wan MLY, Ling KH, El-Nezami H, Wang MF. Wan MLY, et al. Crit Rev Food Sci Nutr. 2019;59(12):1927-1936. doi: 10.1080/10408398.2018.1433629. Epub 2018 Feb 23. Crit Rev Food Sci Nutr. 2019. PMID: 29381385 Review. - Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients.
Shortt C, Hasselwander O, Meynier A, Nauta A, Fernández EN, Putz P, Rowland I, Swann J, Türk J, Vermeiren J, Antoine JM. Shortt C, et al. Eur J Nutr. 2018 Feb;57(1):25-49. doi: 10.1007/s00394-017-1546-4. Epub 2017 Oct 30. Eur J Nutr. 2018. PMID: 29086061 Free PMC article. Review. - Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols.
Kawabata K, Yoshioka Y, Terao J. Kawabata K, et al. Molecules. 2019 Jan 21;24(2):370. doi: 10.3390/molecules24020370. Molecules. 2019. PMID: 30669635 Free PMC article. Review. - Interactions of gut microbiota with dietary polyphenols and consequences to human health.
Tomás-Barberán FA, Selma MV, Espín JC. Tomás-Barberán FA, et al. Curr Opin Clin Nutr Metab Care. 2016 Nov;19(6):471-476. doi: 10.1097/MCO.0000000000000314. Curr Opin Clin Nutr Metab Care. 2016. PMID: 27490306 Review. - Gastrointestinal Simulation Model TWIN-SHIME Shows Differences between Human Urolithin-Metabotypes in Gut Microbiota Composition, Pomegranate Polyphenol Metabolism, and Transport along the Intestinal Tract.
García-Villalba R, Vissenaekens H, Pitart J, Romo-Vaquero M, Espín JC, Grootaert C, Selma MV, Raes K, Smagghe G, Possemiers S, Van Camp J, Tomas-Barberan FA. García-Villalba R, et al. J Agric Food Chem. 2017 Jul 12;65(27):5480-5493. doi: 10.1021/acs.jafc.7b02049. Epub 2017 Jun 28. J Agric Food Chem. 2017. PMID: 28616977
Cited by
- Reinventing gut health: leveraging dietary bioactive compounds for the prevention and treatment of diseases.
Wang Q, Huang H, Yang Y, Yang X, Li X, Zhong W, Wen B, He F, Li J. Wang Q, et al. Front Nutr. 2024 Oct 22;11:1491821. doi: 10.3389/fnut.2024.1491821. eCollection 2024. Front Nutr. 2024. PMID: 39502877 Free PMC article. Review. - The Influence of Flavonoids with -Br, -Cl Atoms and -NO2, -CH3 Groups on the Growth Kinetics and the Number of Pathogenic and Probiotic Microorganisms.
Perz M, Szymanowska D, Kostrzewa-Susłow E. Perz M, et al. Int J Mol Sci. 2024 Aug 27;25(17):9269. doi: 10.3390/ijms25179269. Int J Mol Sci. 2024. PMID: 39273218 Free PMC article. - Unrevealing the mechanisms behind the cardioprotective effect of wheat polyphenolics.
Chakraborty P, Dewanjee S. Chakraborty P, et al. Arch Toxicol. 2024 Nov;98(11):3543-3567. doi: 10.1007/s00204-024-03850-y. Epub 2024 Aug 31. Arch Toxicol. 2024. PMID: 39215839 Review. - Interactions between Dietary Antioxidants, Dietary Fiber and the Gut Microbiome: Their Putative Role in Inflammation and Cancer.
Munteanu C, Schwartz B. Munteanu C, et al. Int J Mol Sci. 2024 Jul 28;25(15):8250. doi: 10.3390/ijms25158250. Int J Mol Sci. 2024. PMID: 39125822 Free PMC article. Review. - Peripheral inflammation as a potential mechanism and preventive strategy for perioperative neurocognitive disorder under general anesthesia and surgery.
Li Y, Li YJ, Fang X, Chen DQ, Yu WQ, Zhu ZQ. Li Y, et al. Front Cell Neurosci. 2024 Jul 3;18:1365448. doi: 10.3389/fncel.2024.1365448. eCollection 2024. Front Cell Neurosci. 2024. PMID: 39022312 Free PMC article. Review.
References
- Hooper LV, Gordon JI. Commensal host-bacterial relationships in the gut. Science. 2001;292:1115–1118. - PubMed
- Sakata H, Yoshioka H, Fujita K. Development of the intestinal flora in very low birth weight infants compared to normal full-term newborns. Eur J Pediatr. 1985;144:186–190. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical