Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis - PubMed (original) (raw)

Meta-Analysis

Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis

Qiang Cai et al. PLoS One. 2015.

Abstract

Background: The association of the aldehyde dehydrogenases-2 (ALDH2) Glu504Lys polymorphism (also named Glu487Lys, or rs671) and cancers has been investigated. This meta-analysis aims to comprehensively assess the influence of this polymorphism on the overall cancer risk.

Methods: Eligible publications were retrieved according to inclusion/exclusion criteria and the data were analyzed using the Review Manager software (V5.2).

Results: A meta-analysis based on 51 case-control studies consisting of 16774 cases and 32060 controls was performed to evaluate the association between the ALDH2 Glu504Lys polymorphism and cancer risk. The comparison of genotypes Lys+ (Lys/Lys and Lys/Glu) with Glu/Glu yielded a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03-1.39, P = 0.02, I2 = 92%). Subgroup analysis by cancer type indicated a significantly increased UADT cancer risk (OR = 1.39, 95%CI: 1.11-1.73, P = 0.004, I2 = 94%) in individuals with the Lys+ genotypes. Subgroup analysis by country indicated that individuals from Japan with the Lys+ genotypes had a significant 38% increased cancer risk (OR = 1.38, 95%CI: 1.12-1.71, P = 0.003, I2 = 93%).

Conclusions: Our results indicated that the ALDH2 Glu504Lys polymorphism is a susceptible loci associated with overall cancers, especially esophageal cancer and among Japanese population.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1

Figure 1. Flow diagram of search strategy and study selection.

Figure 2

Figure 2. Forest plot showed the overall cancer risk in association with the polymorphism of ALDH2 gene Glu504Lys polymorphism.

In the genotypic model, the comparison of Lys+ with Glu/Glu genotype generated a significant 20% increased cancer risk (OR = 1.20, 95%CI: 1.03–1.39, P = 0.02, I2 = 92%).

Figure 3

Figure 3. Forest plot of UADT cancer risk associated with the ALDH2 Glu504Lys polymorphism in position-specific analyses.

Individuals with the variant allele (504Lys) had 52% increased risk of esophageal cancer (OR = 1.52, 95%CI: 1.12–2.08, P = 0.008), 22% risk of head and neck cancer (OR = 1.22, 95%CI: 1.07–1.39, P = 0.003) and 18% risk of gastric cancer (OR = 1.18, 95%CI: 1.03–1.35, P = 0.02).

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