Tissue-resident macrophages: then and now - PubMed (original) (raw)

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Tissue-resident macrophages: then and now

Luke C Davies et al. Immunology. 2015 Apr.

Abstract

Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed as terminally differentiated monocytic phagocytes. They infiltrate tissues during inflammation, and form polarized populations that perform pro-inflammatory or anti-inflammatory functions. Tissue-resident macrophages were regarded as differentiated monocytes, which seed the tissues to perform immune sentinel and homeostatic functions. However, tissue-resident macrophages are not a homogeneous population, but are in fact a grouping of cells with similar functions and phenotypes. In the last decade, it has been revealed that many of these cells are not terminally differentiated and, in most cases, are not derived from haematopoiesis in the adult. Recent research has highlighted that tissue-resident macrophages cannot be grouped into simple polarized categories, especially in vivo, when they are exposed to complex signalling events. It has now been demonstrated that the tissue environment itself is a major controller of macrophage phenotype, and can influence the expression of many genes regardless of origin. This is consistent with the concept that cells within different tissues have diverse responses in inflammation. There is still a mountain to climb in the field, as it evolves to encompass not only tissue-resident macrophage diversity, but also categorization of specific tissue environments and the plasticity of macrophages themselves. This knowledge provides a new perspective on therapeutic strategies, as macrophage subsets can potentially be manipulated to control the inflammatory environment in a tissue-specific manner.

Keywords: Gata6; environmental programming; tissue-resident macrophages.

© 2015 The Authors. Immunology Published by John Wiley & Sons Ltd.

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Figures

Figure 1

Figure 1

Gata6 controls peritoneal macrophage phenotype. Diagram showing recent discoveries on the control of peritoneal macrophage phenotype by Gata6. The yellow cells represent peritoneal omental tissue, B cells are shown as small circular cells, and the large globular cell is a peritoneal resident macrophage. Results from different laboratories are colour coded: green, blue, magenta and orange,.

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