Clustering of multiallele DNA markers near the Huntington's disease gene - PubMed (original) (raw)
Clustering of multiallele DNA markers near the Huntington's disease gene
M E MacDonald et al. J Clin Invest. 1989 Sep.
Abstract
Five highly informative multiallele restriction fragment length polymorphisms (RFLPs) of value for preclinical diagnosis of Huntington's disease (HD) have been genetically characterized. One RFLP was uncovered by expansion of the D4S43 locus while three others are at D4S111 and D4S115, loci defined by NotI-linking clones. The final marker, D4S125, represents a recently discovered VNTR locus. All four loci map closer to the HD gene and to the telomere than D4S10, the original linked marker for HD. In combination with two multiallele RFLPs previously identified for D4S43 and another linked locus, D4S95, these five new multiallele markers will dramatically improve the speed and accuracy of predictive testing in HD, and increase its applicability by maximizing the chances of an informative test for anyone with appropriate family structure.
Similar articles
- Mapping of D4S98/S114/S113 confines the Huntington's defect to a reduced physical region at the telomere of chromosome 4.
Whaley WL, Michiels F, MacDonald ME, Romano D, Zimmer M, Smith B, Leavitt J, Bucan M, Haines JL, Gilliam TC, et al. Whaley WL, et al. Nucleic Acids Res. 1988 Dec 23;16(24):11769-80. doi: 10.1093/nar/16.24.11769. Nucleic Acids Res. 1988. PMID: 2905444 Free PMC article. - Genetic analysis of Huntington disease in Italy.
Ajmar F, Mandich P, Bellone E, Abbruzzese G. Ajmar F, et al. Am J Med Genet. 1991 May 1;39(2):211-4. doi: 10.1002/ajmg.1320390219. Am J Med Genet. 1991. PMID: 1829583 - A linkage study with DNA markers (D4S95, D4S115, and D4S111) in Japanese Huntington disease families.
Watanabe M, Kondo I, Nissato S, Wakisaka A, Toda T, Ikeda J, Wasmuth JJ, Gusella JF, Kanazawa I. Watanabe M, et al. Jpn J Hum Genet. 1993 Jun;38(2):193-201. doi: 10.1007/BF01883710. Jpn J Hum Genet. 1993. PMID: 8102909 - Molecular genetic strategies to investigate Huntington's disease.
Gilliam TC, Gusella JF, Lehrach H. Gilliam TC, et al. Adv Neurol. 1988;48:17-29. Adv Neurol. 1988. PMID: 2891255 Review. No abstract available. - Genetics and molecular biology of Huntington's disease.
Albin RL, Tagle DA. Albin RL, et al. Trends Neurosci. 1995 Jan;18(1):11-4. doi: 10.1016/0166-2236(95)93943-r. Trends Neurosci. 1995. PMID: 7535483 Review.
Cited by
- Linkage disequilibrium and modification of risk for Huntington disease.
Adam S, Theilmann J, Buetow K, Hedrick A, Collins C, Weber B, Huggins M, Hayden M. Adam S, et al. Am J Hum Genet. 1991 Mar;48(3):595-603. Am J Hum Genet. 1991. PMID: 1671809 Free PMC article. - Detection by PCR of a VNTR polymorphism at D4S43.
Horn GT, McClatchey AI, Richards B, MacDonald ME, Gusella JF. Horn GT, et al. Nucleic Acids Res. 1991 Sep 11;19(17):4772. doi: 10.1093/nar/19.17.4772. Nucleic Acids Res. 1991. PMID: 1679922 Free PMC article. - MboI RFLP at the D4S43 (C4H) locus.
Lazarou LP, Snell RG, MacDonald ME, Gusella JF, Wasmuth JJ, Shaw DJ. Lazarou LP, et al. Nucleic Acids Res. 1991 Oct 11;19(19):5445. doi: 10.1093/nar/19.19.5445-a. Nucleic Acids Res. 1991. PMID: 1681512 Free PMC article. No abstract available. - Defining the location of the Huntington disease gene.
Danks DM. Danks DM. Am J Hum Genet. 1993 Jan;52(1):214. Am J Hum Genet. 1993. PMID: 8434592 Free PMC article. No abstract available. - Linkage disequilibrium and recombination make a telomeric site for the Huntington's disease gene unlikely.
Barron L, Curtis A, Shrimpton AE, Holloway S, May H, Snell RG, Brock DJ. Barron L, et al. J Med Genet. 1991 Aug;28(8):520-2. doi: 10.1136/jmg.28.8.520. J Med Genet. 1991. PMID: 1833548 Free PMC article.
References
- Proc Natl Acad Sci U S A. 1979 Oct;76(10):5239-42 - PubMed
- Genomics. 1988 Aug;3(2):129-36 - PubMed
- Nature. 1983 Nov 17-23;306(5940):234-8 - PubMed
- Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6 - PubMed
- Anal Biochem. 1984 Feb;137(1):266-7 - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical