Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression - PubMed (original) (raw)
. 1989 May;217(1):149-54.
doi: 10.1007/BF00330954.
Affiliations
- PMID: 2570346
- DOI: 10.1007/BF00330954
Structure of the HOM2 gene of Saccharomyces cerevisiae and regulation of its expression
D Thomas et al. Mol Gen Genet. 1989 May.
Abstract
In Saccharomyces cerevisiae the HOM2 gene encodes aspartic semi-aldehyde dehydrogenase (ASA DH). The synthesis of this enzyme had been shown to be derepressed by growth in the presence of high concentrations of methionine. In the present work we have cloned and sequenced the HOM2 gene and found that the promoter region of this gene bears one copy of the consensus sequence for general control of amino acid synthesis. This prompted us to study the regulation of the expression of the HOM2 gene. We have found that ASA DH is the first reported enzyme of the related threonine and methionine pathway to be regulated by the general control of amino acid synthesis.
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References
- Biochemistry. 1973 Jun 5;12(12):2264-70 - PubMed
- Nucleic Acids Res. 1981 Jul 10;9(13):2989-98 - PubMed
- Gene. 1985;35(1-2):27-32 - PubMed
- Mol Gen Genet. 1987 Dec;210(2):307-13 - PubMed
- Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5 - PubMed
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