Insulin resistance and hypertension: new insights - PubMed (original) (raw)

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doi: 10.1038/ki.2014.392.

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• PMID: 25723632
• DOI: 10.1038/ki.2014.392

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Insulin resistance and hypertension: new insights

Manoocher Soleimani. Kidney Int. 2015 Mar.

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Abstract

Insulin resistance is associated with hypertension. Nakamura et al. demonstrate in rodents and humans with insulin resistance that while the stimulatory effect of insulin on glucose uptake in adipocytes, mediated via insulin receptor substrate 1 (IRS1), was severely diminished, its effect on salt reabsorption in the kidney proximal tubule, mediated via IRS2, was preserved. Compensatory hyperinsulinemia in individuals with insulin resistance may enhance salt absorption in the proximal tubule, resulting in a state of salt overload and hypertension.

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• Preserved Na/HCO3 cotransporter sensitivity to insulin may promote hypertension in metabolic syndrome.
  Nakamura M, Yamazaki O, Shirai A, Horita S, Satoh N, Suzuki M, Hamasaki Y, Noiri E, Kume H, Enomoto Y, Homma Y, Seki G. Nakamura M, et al. Kidney Int. 2015 Mar;87(3):535-42. doi: 10.1038/ki.2014.351. Epub 2014 Oct 29. Kidney Int. 2015. PMID: 25354240

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