Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae) - PubMed (original) (raw)
. 2015 Jun;69(6):299-313.
doi: 10.1002/syn.21814.
Affiliations
- PMID: 25727065
- DOI: 10.1002/syn.21814
Recruitment of striatonigral disinhibitory and nigrotectal inhibitory GABAergic pathways during the organization of defensive behavior by mice in a dangerous environment with the venomous snake Bothrops alternatus (Reptilia, Viperidae)
Rafael Carvalho Almada et al. Synapse. 2015 Jun.
Abstract
The neuropsychopharmacological basis of fear- or panic-related behavior has been the focus of several studies. Some mesencephalic tectum (MT) structures, such as the superior colliculus (SC) and dorsal periaqueductal gray matter (dPAG), are considered to be responsible for the control of defensive responses evoked during threatening situations. Furthermore, the pars reticulata of the substantia nigra (SNpr) sends inputs to the SC that can work as a sensory channel to MT neurons fundamental for the elaboration of defensive responses. The purpose of the present study was to investigate the role of striato-nigral GABAergic inputs in the activity of nigro-tectal outputs during the elaboration of defensive behavior using a GABA(A) receptor selective blockade in the MT of mice confronted pre-treated with Bothrops alternatus. Mice with injections of physiological saline into the SNpr and treated with a GABA(A) receptor selective antagonist in the MT displayed an increase in panic-related behavior, expressed by an increase in the duration of freezing, frequency of nonoriented escape and frequency of total escape responses during the confrontation with the snake. However, intra-SNpr injections of cobalt chloride followed by MT injections of bicuculline caused a significant decrease in the duration of freezing and total escape responses. In addition, intra-SNpr injections of lidocaine followed by MT injections of bicuculline caused an increase in panic-related behavior. The results highlight the involvement of SNpr and MT structures in the organization of defensive behaviors and suggest an inhibitory control of striatonigral-nigrotectal pathways during the elaboration of fear- and panic-related behavior.
Keywords: dorsal periaqueductal gray matter; mesencephalic tectum; nigro-tectal pathways; prey vs.venomous snake paradigm; striato-nigral pathways; γ-amino-butyric acid.
© 2015 Wiley Periodicals, Inc.
Similar articles
- Endocannabinoid signaling mechanisms in the substantia nigra pars reticulata modulate GABAergic nigrotectal pathways in mice threatened by urutu-cruzeiro venomous pit viper.
Almada RC, Roncon CM, Elias-Filho DH, Coimbra NC. Almada RC, et al. Neuroscience. 2015 Sep 10;303:503-14. doi: 10.1016/j.neuroscience.2015.06.048. Epub 2015 Jun 30. Neuroscience. 2015. PMID: 26141842 - Functional and ultrastructural neuroanatomy of interactive intratectal/tectonigral mesencephalic opioid inhibitory links and nigrotectal GABAergic pathways: involvement of GABAA and mu1-opioid receptors in the modulation of panic-like reactions elicited by electrical stimulation of the dorsal midbrain.
Ribeiro SJ, Ciscato JG Jr, de Oliveira R, de Oliveira RC, D'Angelo-Dias R, Carvalho AD, Felippotti TT, Rebouças EC, Castellan-Baldan L, Hoffmann A, Corrêa SA, Moreira JE, Coimbra NC. Ribeiro SJ, et al. J Chem Neuroanat. 2005 Dec;30(4):184-200. doi: 10.1016/j.jchemneu.2005.07.004. Epub 2005 Sep 2. J Chem Neuroanat. 2005. PMID: 16140499 - Gabaergic regulation of the neural organization of fear in the midbrain tectum.
Brandão ML, Borelli KG, Nobre MJ, Santos JM, Albrechet-Souza L, Oliveira AR, Martinez RC. Brandão ML, et al. Neurosci Biobehav Rev. 2005;29(8):1299-311. doi: 10.1016/j.neubiorev.2005.04.013. Epub 2005 Aug 9. Neurosci Biobehav Rev. 2005. PMID: 16084589 Review.
Cited by
- Prefrontal control of superior colliculus modulates innate escape behavior following adversity.
Ritter A, Habusha S, Givon L, Edut S, Klavir O. Ritter A, et al. Nat Commun. 2024 Mar 9;15(1):2158. doi: 10.1038/s41467-024-46460-z. Nat Commun. 2024. PMID: 38461293 Free PMC article. - Augmented anandamide signalling in the substantia nigra pars reticulata mediates panicolytic-like effects in mice confronted by Crotalus durissus terrificus pit vipers.
Almada RC, Falconi-Sobrinho LL, da Silva JA, Wotjak CT, Coimbra NC. Almada RC, et al. Psychopharmacology (Berl). 2022 Sep;239(9):2753-2769. doi: 10.1007/s00213-022-06127-3. Epub 2022 Jun 2. Psychopharmacology (Berl). 2022. PMID: 35650304 - Cannabidiol-induced panicolytic-like effects and fear-induced antinociception impairment: the role of the CB1 receptor in the ventromedial hypothalamus.
Khan AU, Falconi-Sobrinho LL, Dos Anjos-Garcia T, de Fátima Dos Santos Sampaio M, de Souza Crippa JA, Menescal-de-Oliveira L, Coimbra NC. Khan AU, et al. Psychopharmacology (Berl). 2020 Apr;237(4):1063-1079. doi: 10.1007/s00213-019-05435-5. Epub 2020 Jan 9. Psychopharmacology (Berl). 2020. PMID: 31919563 - Opposing roles of dorsomedial hypothalamic CB1 and TRPV1 receptors in anandamide signaling during the panic-like response elicited in mice by Brazilian rainbow Boidae snakes.
Dos Anjos-Garcia T, Coimbra NC. Dos Anjos-Garcia T, et al. Psychopharmacology (Berl). 2019 Jun;236(6):1863-1874. doi: 10.1007/s00213-019-5170-2. Epub 2019 Jan 29. Psychopharmacology (Berl). 2019. PMID: 30694375 - Amygdala activity for the modulation of goal-directed behavior in emotional contexts.
Maeda K, Kunimatsu J, Hikosaka O. Maeda K, et al. PLoS Biol. 2018 Jun 5;16(6):e2005339. doi: 10.1371/journal.pbio.2005339. eCollection 2018 Jun. PLoS Biol. 2018. PMID: 29870524 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous