Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man - PubMed (original) (raw)
Clinical Trial
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
P Vallance et al. Lancet. 1989.
Abstract
NG monomethyl-L-arginine (L-NMMA), a specific inhibitor of the synthesis of endothelium-derived nitric oxide (NO), was infused into the brachial arteries of healthy volunteers to study the role of NO in the control of forearm blood flow. L-NMMA caused a 50% fall in basal blood flow and attenuated the dilator response to infused acetylcholine but not that to glyceryl trinitrate. These results indicate that the dilator action of endothelium-derived NO contributes to the control of basal and stimulated regional blood flow in man. Impairment of production of NO might account for the abnormalities in vascular reactivity that characterise a wide variety of disease states.
Comment in
- Role of endothelium-derived nitric oxide in maintenance of low fetal vascular resistance in placenta.
Gude NM, King RG, Brennecke SP. Gude NM, et al. Lancet. 1990 Dec 22-29;336(8730):1589-90. doi: 10.1016/0140-6736(90)93374-x. Lancet. 1990. PMID: 1979408 No abstract available.
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