Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction - PubMed (original) (raw)
Pathogenesis of Crohn's disease: multifocal gastrointestinal infarction
A J Wakefield et al. Lancet. 1989.
Abstract
In a prospective study, specimens of resected small and large intestine from fifteen patients with Crohn's disease were prepared by heparin-saline vascular perfusion, followed by either resin casting of the mesenteric vascular supply and tissue maceration or glutaraldehyde perfusion-fixation, resin casting, and tissue clearance. The specimens were examined by macrophotography, histopathology, and either scanning or transmission electronmicroscopy. A pathogenetic sequence of events in Crohn's disease was seen--vascular injury, focal arteritis, fibrin deposition, arterial occlusion mainly at the level of the muscularis propria, followed by tissue infarction or neovascularisation. These features were confined to segments of intestine affected by Crohn's disease and did not occur in normal bowel. The findings suggest that Crohn's disease is mediated by multifocal gastrointestinal infarction. This pathogenetic process is compatible with many of the clinical features of Crohn's disease, and its recognition has important implications for the identification of the primary cause of the illness and advances in clinical management.
Comment in
- Pathogenesis of Crohn's disease.
Gasser P, Affolter H. Gasser P, et al. Lancet. 1990 Mar 3;335(8688):551. doi: 10.1016/0140-6736(90)90792-4. Lancet. 1990. PMID: 1968568 No abstract available. - Pathogenesis of Crohn's disease.
Price AB, Talbot IC, Thompson H, Williams GT. Price AB, et al. Lancet. 1990 Apr 7;335(8693):858. doi: 10.1016/0140-6736(90)90975-b. Lancet. 1990. PMID: 1969583 No abstract available. - Pathogenesis of Crohn's disease.
[No authors listed] [No authors listed] Lancet. 1989 Dec 16;2(8677):1459-60. Lancet. 1989. PMID: 2574391 No abstract available.
Similar articles
- Crohn's disease: pathogenesis and persistent measles virus infection.
Wakefield AJ, Ekbom A, Dhillon AP, Pittilo RM, Pounder RE. Wakefield AJ, et al. Gastroenterology. 1995 Mar;108(3):911-6. doi: 10.1016/0016-5085(95)90467-0. Gastroenterology. 1995. PMID: 7875495 Review. - The pathogenesis of Crohn's disease.
Pounder RE. Pounder RE. J Gastroenterol. 1994 Jul;29 Suppl 7:11-5. J Gastroenterol. 1994. PMID: 7921140 Review. - Ulceration of the ileum in Crohn's disease: correlation with vascular anatomy.
Anthony A, Dhillon AP, Pounder RE, Wakefield AJ. Anthony A, et al. J Clin Pathol. 1997 Dec;50(12):1013-7. doi: 10.1136/jcp.50.12.1013. J Clin Pathol. 1997. PMID: 9516884 Free PMC article. - Granulomatous vasculitis in Crohn's disease.
Wakefield AJ, Sankey EA, Dhillon AP, Sawyerr AM, More L, Sim R, Pittilo RM, Rowles PM, Hudson M, Lewis AA, et al. Wakefield AJ, et al. Gastroenterology. 1991 May;100(5 Pt 1):1279-87. Gastroenterology. 1991. PMID: 2013373 - Vascular compromise prior to intestinal manifestations of Crohn's disease in a 14-year-old girl.
Van Elburg RM, Henar EL, Bijleveld CM, Prins TR, Heymans HS. Van Elburg RM, et al. J Pediatr Gastroenterol Nutr. 1992 Jan;14(1):97-100. doi: 10.1097/00005176-199201000-00018. J Pediatr Gastroenterol Nutr. 1992. PMID: 1349349
Cited by
- Contrast-enhanced ultrasonography (CEUS) vs. MRI of the small bowel in the evaluation of Crohn's disease activity.
Malagò R, D'Onofrio M, Mantovani W, D'Alpaos G, Foti G, Pezzato A, Caliari G, Cusumano D, Benini L, Pozzi Mucelli R. Malagò R, et al. Radiol Med. 2012 Mar;117(2):268-81. doi: 10.1007/s11547-011-0783-5. Epub 2012 Jan 21. Radiol Med. 2012. PMID: 22271005 - Macrophage procoagulant activity as an assay of cellular hypersensitivity to gluten peptides in coeliac disease.
Devery JM, Geczy CL, DeClarle D, Skerritt JH, Krillis SA. Devery JM, et al. Clin Exp Immunol. 1990 Nov;82(2):333-7. doi: 10.1111/j.1365-2249.1990.tb05448.x. Clin Exp Immunol. 1990. PMID: 2242613 Free PMC article. - Antineutrophil cytoplasmic antibodies (ANCA) directed against cathepsin G in ulcerative colitis, Crohn's disease and primary sclerosing cholangitis.
Halbwachs-Mecarelli L, Nusbaum P, Noël LH, Reumaux D, Erlinger S, Grünfeld JP, Lesavre P. Halbwachs-Mecarelli L, et al. Clin Exp Immunol. 1992 Oct;90(1):79-84. doi: 10.1111/j.1365-2249.1992.tb05835.x. Clin Exp Immunol. 1992. PMID: 1327593 Free PMC article. - Small bowel infarction mimicking Crohn's ileitis.
Thuluvath PJ, Feher MD, Wiggins J. Thuluvath PJ, et al. Postgrad Med J. 1991 Sep;67(791):837-9. doi: 10.1136/pgmj.67.791.837. Postgrad Med J. 1991. PMID: 1946130 Free PMC article. - Massive Lower Gastrointestinal Hemorrhage in Crohn's Disease.
Korzenik JR. Korzenik JR. Curr Treat Options Gastroenterol. 2000 Jun;3(3):211-216. doi: 10.1007/s11938-000-0024-9. Curr Treat Options Gastroenterol. 2000. PMID: 11097738
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical