A new DNA marker tightly linked to the fragile X locus (FRAXA) - PubMed (original) (raw)
. 1989 Dec 8;246(4935):1298-300.
doi: 10.1126/science.2573953.
Affiliations
- PMID: 2573953
- DOI: 10.1126/science.2573953
A new DNA marker tightly linked to the fragile X locus (FRAXA)
G K Suthers et al. Science. 1989.
Abstract
The fragile X syndrome is the most common cause of familial mental retardation. Genetic counseling and gene isolation are hampered by a lack of DNA markers close to the disease locus. Two somatic cell hybrids that each contain a human X chromosome with a breakpoint close to the fragile X locus have been characterized. A new DNA marker (DXS296) lies between the chromosome breakpoints and is the closest marker to the fragile X locus yet reported. The Hunter syndrome gene, which causes iduronate sulfatase deficiency, is located at the X chromosome breakpoint that is distal to this new marker, thus localizing the Hunter gene distal to the fragile X locus.
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