Obesity in breast cancer--what is the risk factor? - PubMed (original) (raw)
Review
Obesity in breast cancer--what is the risk factor?
F R James et al. Eur J Cancer. 2015 Apr.
Abstract
Environmental factors influence breast cancer incidence and progression. High body mass index (BMI) is associated with increased risk of post-menopausal breast cancer and with poorer outcome in those with a history of breast cancer. High BMI is generally interpreted as excess adiposity (overweight or obesity) and the World Cancer Research Fund judged that the associations between BMI and incidence of breast cancer were due to body fatness. Although BMI is the most common measure used to characterise body composition, it cannot distinguish lean mass from fat mass, or characterise body fat distribution, and so individuals with the same BMI can have different body composition. In particular, the relation between BMI and lean or fat mass may differ between people with or without disease. The question therefore arises as to what aspect or aspects of body composition are causally linked to the poorer outcome of breast cancer patients with high BMI. This question is not addressed in the literature. Most studies have used BMI, without discussion of its shortcomings as a marker of body composition, leading to potentially important misinterpretation. In this article we review the different measurements used to characterise body composition in the literature, and how they relate to breast cancer risk and prognosis. Further research is required to better characterise the relation of body composition to breast cancer.
Keywords: Body composition; Body fatness; Breast cancer; Fat free mass; Fat mass; Intervention; Prognosis; Risk factor.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Similar articles
- Early breast cancer: why does obesity affect prognosis?
Heetun A, Cutress RI, Copson ER. Heetun A, et al. Proc Nutr Soc. 2018 Nov;77(4):369-381. doi: 10.1017/S0029665118000447. Epub 2018 Jun 4. Proc Nutr Soc. 2018. PMID: 29860965 Review. - Accuracy of body mass index to determine obesity in women with breast cancer: an observational study of Taiwanese sample.
Liu LN, Miaskowski C, Wang JS, Chen SC, Chen ML. Liu LN, et al. Int J Nurs Stud. 2010 Aug;47(8):994-1000. doi: 10.1016/j.ijnurstu.2010.01.002. Epub 2010 Feb 4. Int J Nurs Stud. 2010. PMID: 20129610 Review. - Overweight, obesity and breast cancer prognosis: optimal body size indicator cut-points.
Majed B, Moreau T, Asselain B; Curie Institute Breast Cancer Group. Majed B, et al. Breast Cancer Res Treat. 2009 May;115(1):193-203. doi: 10.1007/s10549-008-0065-7. Epub 2008 Jun 12. Breast Cancer Res Treat. 2009. PMID: 18546073 - [Android obesity and breast cancer risk].
Petrovanu C, Coman AE, Murariu GC, Petrovanu R. Petrovanu C, et al. Rev Med Chir Soc Med Nat Iasi. 2007 Oct-Dec;111(4):872-6. Rev Med Chir Soc Med Nat Iasi. 2007. PMID: 18389772 Romanian. - Growth trajectories associated with adult obesity.
Rolland-Cachera MF, Péneau S. Rolland-Cachera MF, et al. World Rev Nutr Diet. 2013;106:127-34. doi: 10.1159/000342564. Epub 2013 Feb 11. World Rev Nutr Diet. 2013. PMID: 23428691 Review.
Cited by
- Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer.
Maliniak ML, Miller-Kleinhenz J, Cronin-Fenton DP, Lash TL, Gogineni K, Janssen EAM, McCullough LE. Maliniak ML, et al. Cancers (Basel). 2021 May 6;13(9):2222. doi: 10.3390/cancers13092222. Cancers (Basel). 2021. PMID: 34066392 Free PMC article. Review. - A nomogram for survival prediction in 275,812 U.S. patients with breast cancer: a population-based cohort study based on the SEER database.
Wang Z, Xing L, Luo X, Ren G. Wang Z, et al. Gland Surg. 2022 Jul;11(7):1166-1179. doi: 10.21037/gs-22-321. Gland Surg. 2022. PMID: 35935563 Free PMC article. - Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review.
Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Łukasiewicz S, et al. Cancers (Basel). 2021 Aug 25;13(17):4287. doi: 10.3390/cancers13174287. Cancers (Basel). 2021. PMID: 34503097 Free PMC article. Review. - Obesity Is Associated with Immunometabolic Changes in Adipose Tissue That May Drive Treatment Resistance in Breast Cancer: Immune-Metabolic Reprogramming and Novel Therapeutic Strategies.
Savva C, Copson E, Johnson PWM, Cutress RI, Beers SA. Savva C, et al. Cancers (Basel). 2023 Apr 24;15(9):2440. doi: 10.3390/cancers15092440. Cancers (Basel). 2023. PMID: 37173907 Free PMC article. Review. - Relationship of body mass index with BRAF (V600E) mutation in papillary thyroid cancer.
Shi RL, Qu N, Liao T, Wei WJ, Lu ZW, Ma B, Wang YL, Ji QH. Shi RL, et al. Tumour Biol. 2016 Jun;37(6):8383-90. doi: 10.1007/s13277-015-4718-y. Epub 2016 Jan 5. Tumour Biol. 2016. PMID: 26733165
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical