Association of peripheral total and differential leukocyte counts with obesity-related complications in young adults - PubMed (original) (raw)

Aya Yoshimura et al. Obes Facts. 2015.

Abstract

Objective: Obesity has been demonstrated to be associated with elevated leukocytes in adults and children. This study assessed the associations between peripheral total and differential leukocyte counts and obesity-related complications in young adults.

Methods: 12 obese (median age 21.5 (range 19-28) years, median BMI 35.7 (range 32.0-44.9) kg/m(2)) and 11 normal (median age 23 (range 18-27) years, median BMI 19.5 (range 18.1-21.7) kg/m(2)) adults were enrolled. Complete blood count and serum levels of liver enzymes, fasting blood glucose, insulin and lipids were measured, and the homeostasis model assessment of insulin resistance was calculated. Fat mass was calculated using a bioimpedance analysis device, and ultrasonography was performed to measure fat thickness and to detect fatty change of the liver.

Results: Total leukocyte and monocyte counts were significantly increased in obese young adults. Total leukocyte count was associated with liver enzyme levels, insulin resistance as well as visceral and subcutaneous fat thickness. Neutrophil count was associated with insulin resistance. Lymphocyte count was associated with serum liver enzymes, insulin resistance, and dyslipidemia. Monocyte count was associated with serum liver enzyme, insulin resistance, visceral and subcutaneous fat thickness, body fat mass, and percentage body fat.

Conclusion: The results of this study suggest that chronic low-grade systemic inflammation is associated with obesity-related complications such as nonalcoholic fatty liver disease, insulin resistance, and dyslipidemia in young adults.

© 2015 S. Karger GmbH, Freiburg.

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Figures

Fig. 1

Fig. 1

Correlation of peripheral total leukocyte, neutrophil, lymphocyte and monocyte counts with serum levels of A aspartate aminotransferase (AST), B alanine aminotransferase (ALT), C γ-glutamyl transpeptidase (γ-GTP), and D choline esterase (ChE). Open squares represent control subjects. Closed squares represent obese subjects

Fig. 2

Fig. 2

Correlation of peripheral total leukocyte, neutrophil, lymphocyte and monocyte counts with A fasting blood glucose (FBG), B hemoglobin A1c (HbA1c), C insulin, and D homeostasis model assessment of insulin resistance (HOMA-IR). Open squares represent control subjects. Closed squares represent obese subjects.

Fig. 3

Fig. 3

Correlation of peripheral total leukocyte, neutrophil, lymphocyte and monocyte counts with A total cholesterol (T-CHO), B low-density lipoprotein cholesterol (LDL-C), C high-density lipoprotein cholesterol (HDL-C), and D triglycerides (TG). Open squares represent control subjects. Closed squares represent obese subjects.

Fig. 4

Fig. 4

Correlation of peripheral total leukocyte, neutrophil, lymphocyte and monocyte counts with A visceral fat thickness measured by ultrasonography, B subcutaneous fat thickness measured by ultrasonography, C body fat mass calculated by a bioimpedance analysis device, and D percentage body fat calculated by a bioimpedance analysis device. Open squares represent control subjects. Closed squares represent obese subjects.

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