Strategy use, planning, and rule acquisition deficits in spinocerebellar ataxia type 2 patients - PubMed (original) (raw)
Strategy use, planning, and rule acquisition deficits in spinocerebellar ataxia type 2 patients
Israel Vaca-Palomares et al. J Int Neuropsychol Soc. 2015 Mar.
Abstract
Our goal was to improve spinocerebellar ataxia type 2 (SCA2) cognitive profile characterization by testing the hypothesis that strategy, planning and rule acquisition capacities are affected in SCA2. Forty one patients with SCA2 were evaluated with the Spatial Working Memory (SWM), the Stockings of Cambridge (SOC), and the Intra-Extra Dimensional Shift (IED) tests of the Executive module of the Cambridge Neuropsychological Testing Automated Battery (CANTAB). Paired Associates Learning (PAL) and Delayed Matching to Sample (DMS) from the CANTAB memory module were also assessed to corroborate previous findings. Motor deterioration was measured using the Scale for the Assessment and Rating of Ataxia (SARA). We found significant SCA2 related deficits in strategy, planning, and rule acquisition. Our results also corroborated significant memory deficits in these patients with SCA2. Further analysis also showed that patients with large motor deterioration had poorer associative learning and spatial planning scores. Patients with SCA2 show strategy, planning, and rule acquisition deficits as revealed with the CANTAB battery. These deficits should be noted when planning an effective therapy for these patients.
Keywords: CANTAB.
Similar articles
- Cognitive Deficits Correlate with White Matter Deterioration in Spinocerebellar Ataxia Type 2.
Hernandez-Castillo CR, Vaca-Palomares I, Galvez V, Campos-Romo A, Diaz R, Fernandez-Ruiz J. Hernandez-Castillo CR, et al. J Int Neuropsychol Soc. 2016 Apr;22(4):486-91. doi: 10.1017/S1355617716000084. Epub 2016 Feb 18. J Int Neuropsychol Soc. 2016. PMID: 26888086 - Executive function deficits in children with fetal alcohol spectrum disorders (FASD) measured using the Cambridge Neuropsychological Tests Automated Battery (CANTAB).
Green CR, Mihic AM, Nikkel SM, Stade BC, Rasmussen C, Munoz DP, Reynolds JN. Green CR, et al. J Child Psychol Psychiatry. 2009 Jun;50(6):688-97. doi: 10.1111/j.1469-7610.2008.01990.x. Epub 2008 Oct 23. J Child Psychol Psychiatry. 2009. PMID: 19175817 - Cognitive deficits in spinocerebellar ataxia 2.
Bürk K, Globas C, Bösch S, Gräber S, Abele M, Brice A, Dichgans J, Daum I, Klockgether T. Bürk K, et al. Brain. 1999 Apr;122 ( Pt 4):769-77. doi: 10.1093/brain/122.4.769. Brain. 1999. PMID: 10219787 - Thalamic involvement in a spinocerebellar ataxia type 2 (SCA2) and a spinocerebellar ataxia type 3 (SCA3) patient, and its clinical relevance.
Rüb U, Del Turco D, Del Tredici K, de Vos RA, Brunt ER, Reifenberger G, Seifried C, Schultz C, Auburger G, Braak H. Rüb U, et al. Brain. 2003 Oct;126(Pt 10):2257-72. doi: 10.1093/brain/awg234. Epub 2003 Jul 7. Brain. 2003. PMID: 12847080 Review. - Rare association of motor neuron disease and spinocerebellar ataxia type 2 (SCA2): a new case and review of the literature.
Nanetti L, Fancellu R, Tomasello C, Gellera C, Pareyson D, Mariotti C. Nanetti L, et al. J Neurol. 2009 Nov;256(11):1926-8. doi: 10.1007/s00415-009-5237-9. Epub 2009 Jul 31. J Neurol. 2009. PMID: 19644730 Review.
Cited by
- Spinocerebellar Ataxia Type 2: Clinicogenetic Aspects, Mechanistic Insights, and Management Approaches.
Velázquez-Pérez LC, Rodríguez-Labrada R, Fernandez-Ruiz J. Velázquez-Pérez LC, et al. Front Neurol. 2017 Sep 11;8:472. doi: 10.3389/fneur.2017.00472. eCollection 2017. Front Neurol. 2017. PMID: 28955296 Free PMC article. Review. - Hereditary Ataxias in Cuba: A Nationwide Epidemiological and Clinical Study in 1001 Patients.
Velázquez-Pérez L, Medrano-Montero J, Rodríguez-Labrada R, Canales-Ochoa N, Campins Alí J, Carrillo Rodes FJ, Rodríguez Graña T, Hernández Oliver MO, Aguilera Rodríguez R, Domínguez Barrios Y, Torres Vega R, Flores Angulo L, Cordero Navarro NY, Sigler Villanueva AA, Gámez Rodríguez O, Sagaró Zambrano I, Navas Napóles NY, García Zacarías J, Serrano Barrera OR, Ramírez Bautista MB, Estupiñán Rodríguez A, Guerra Rondón LA, Vázquez-Mojena Y, González-Zaldivar Y, Almaguer Mederos LE, Leyva-Mérida A; Cuban Hereditary Ataxias Network. Velázquez-Pérez L, et al. Cerebellum. 2020 Apr;19(2):252-264. doi: 10.1007/s12311-020-01107-9. Cerebellum. 2020. PMID: 31981095 - The Relationships Between Ataxia and Cognition in Spinocerebellar Ataxia Type 2.
Gigante AF, Lelli G, Romano R, Pellicciari R, Di Candia A, Mancino PV, Pau M, Fiore P, Defazio G. Gigante AF, et al. Cerebellum. 2020 Feb;19(1):40-47. doi: 10.1007/s12311-019-01079-5. Cerebellum. 2020. PMID: 31637587 - The Effect of Chronic Alprazolam Intake on Memory, Attention, and Psychomotor Performance in Healthy Human Male Volunteers.
Chowdhury ZS, Morshed MM, Shahriar M, Bhuiyan MA, Islam SM, Bin Sayeed MS. Chowdhury ZS, et al. Behav Neurol. 2016;2016:3730940. doi: 10.1155/2016/3730940. Epub 2016 Jul 4. Behav Neurol. 2016. PMID: 27462136 Free PMC article. Clinical Trial. - Cognitive impairment and its neuroimaging correlates in spinocerebellar ataxia 2.
Stezin A, Bhardwaj S, Hegde S, Jain S, Bharath RD, Saini J, Pal PK. Stezin A, et al. Parkinsonism Relat Disord. 2021 Apr;85:78-83. doi: 10.1016/j.parkreldis.2021.02.028. Epub 2021 Mar 13. Parkinsonism Relat Disord. 2021. PMID: 33756405 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Research Materials