New perspectives on the prevalence of hypertrophic cardiomyopathy - PubMed (original) (raw)
Review
. 2015 Mar 31;65(12):1249-1254.
doi: 10.1016/j.jacc.2015.01.019.
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- PMID: 25814232
- DOI: 10.1016/j.jacc.2015.01.019
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Review
New perspectives on the prevalence of hypertrophic cardiomyopathy
Christopher Semsarian et al. J Am Coll Cardiol. 2015.
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Abstract
Hypertrophic cardiomyopathy (HCM) is an important genetic heart muscle disease for which prevalence in the general population has not been completely resolved. For the past 20 years, most data have supported the occurrence of HCM at about 1 in 500. However, the authors have interrogated a number of relevant advances in cardiovascular medicine, including widespread fee-for-service genetic testing, population genetic studies, and contemporary diagnostic imaging, as well as a greater index of suspicion and recognition for both the clinically expressed disease and the gene-positive-phenotype-negative subset (at risk for developing the disease). Accounting for the potential impact of these initiatives on disease occurrence, the authors have revisited the prevalence of HCM in the general population. They suggest that HCM is more common than previously estimated, which may enhance its recognition in the practicing cardiovascular community, allowing more timely diagnosis and the implementation of appropriate treatment options for many patients.
Keywords: genetics; hypertrophic cardiomyopathy; magnetic resonance imaging; sudden death.
Copyright © 2015 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Comment in
- What Is the True Prevalence of Hypertrophic Cardiomyopathy?
Baudhuin LM, Kotzer KE, Kluge ML, Maleszewski JJ. Baudhuin LM, et al. J Am Coll Cardiol. 2015 Oct 20;66(16):1845-1846. doi: 10.1016/j.jacc.2015.07.074. J Am Coll Cardiol. 2015. PMID: 26483113 No abstract available. - Reply: What Is the True Prevalence of Hypertrophic Cardiomyopathy?
Semsarian C, Ingles J, Maron MS, Maron BJ. Semsarian C, et al. J Am Coll Cardiol. 2015 Oct 20;66(16):1846-1847. doi: 10.1016/j.jacc.2015.07.073. J Am Coll Cardiol. 2015. PMID: 26483114 No abstract available.
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