Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life - PubMed (original) (raw)
. 2015 Apr;135(4):617-26.
doi: 10.1542/peds.2014-3407.
Affiliations
- PMID: 25825533
- DOI: 10.1542/peds.2014-3407
Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life
Antti Saari et al. Pediatrics. 2015 Apr.
Abstract
Objective: Antibiotics have direct effects on the human intestinal microbiota, particularly in infancy. Antibacterial agents promote growth in farm animals by unknown mechanisms, but little is known about their effects on human weight gain. Our aim was to evaluate the impact of antibiotic exposure during infancy on weight and height in healthy Finnish children.
Methods: The population-based cohort comprised 6114 healthy boys and 5948 healthy girls having primary care weight and height measurements and drug purchase data from birth to 24 months. BMI and height, expressed as z-scores at the median age of 24 months (interquartile range 24 to 26 months), were compared between children exposed and unexposed to antibiotics using analysis of covariance with perinatal factors as covariates.
Results: Exposed children were on average heavier than unexposed children (adjusted BMI-for-age z-score difference in boys 0.13 SD [95% confidence interval 0.07 to 0.19, P < .001] and in girls 0.07 SD [0.01 to 0.13, P < .05]). The effect was most pronounced after exposure to macrolides before 6 months of age (boys 0.28 [0.11 to 0.46]; girls 0.23 [0.04 to 0.42]) or >1 exposure (boys 0.20 [0.10 to 0.30]; girls 0.13 [0.03 to 0.22]).
Conclusions: Antibiotic exposure before 6 months of age, or repeatedly during infancy, was associated with increased body mass in healthy children. Such effects may play a role in the worldwide childhood obesity epidemic and highlight the importance of judicious use of antibiotics during infancy, favoring narrow-spectrum antibiotics.
Keywords: BMI; anti-bacterial agents; antibiotics; body weight; growth; height; microbiota; overweight; weight.
Copyright © 2015 by the American Academy of Pediatrics.
Comment in
- Do antibiotics cause obesity?
[No authors listed] [No authors listed] Arch Dis Child. 2015 Jul;100(7):622. doi: 10.1136/archdischild-2015-308955. Epub 2015 Jun 2. Arch Dis Child. 2015. PMID: 26038310 No abstract available.
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