Evaluating the effect of oral administration of Echinacea hydroethanolic extract on the immune system in dog - PubMed (original) (raw)
doi: 10.1111/aap.12024. Epub 2015 Mar 30.
Affiliations
- PMID: 25832590
- DOI: 10.1111/aap.12024
Evaluating the effect of oral administration of Echinacea hydroethanolic extract on the immune system in dog
S Torkan et al. Auton Autacoid Pharmacol. 2015 Jul.
Abstract
This study was designed to evaluate the effects of oral administration of Echinacea hydroethanolic extract on the dog's immune system. The study was performed on 14 dogs that were referred to the veterinary clinic. These dogs were randomly allocated to two equal treatment groups. The first group received 1 ml of 5% Echinacea hydroethanolic extract two times a day for 2 months, and the second group received a placebo (water). To do haematology and immunology tests, the dogs were bled on days 0, 30 and 60. Blood tests, including packed cell volume (PCV), haemoglobin (Hb), red blood cell count (RBC), white blood cell count (WBC), counting neutrophils (Nut), lymphocytes (Lym), monocytes (Mon), eosinophils (Eos), basophils (Baso) and B cell, were performed. Furthermore, safety factor IgM and per cent of phagocytosis and phagocyte were measured from the blood sample. The results showed that in the group which received Echinacea PCV, Hb, RBC count, WBC count, Lym, Nut, the per cent of phagocytosis and IgM significantly increased (P < 0.05). Moreover, positive effects of Echinacea plant on the immune system were observed. There was a significant change in HTC, RBC, Hb over time in the group that received Echinacea and the per cent of phagocytosis and IgM (P < 0.05). The study establishes that these extracts might have appreciable immunostimulatory activity. However, further studies are required to confirm these findings.
Keywords: Echinacea; dog; immune system; oral administration.
© 2015 John Wiley & Sons Ltd.
Similar articles
- Immunological and haematinic consequences of feeding a standardised Echinacea (Echinacea angustifolia) extract to healthy horses.
O'Neill W, McKee S, Clarke AF. O'Neill W, et al. Equine Vet J. 2002 May;34(3):222-7. doi: 10.2746/042516402776186001. Equine Vet J. 2002. PMID: 12108738 Clinical Trial. - Echinacea purpurea stimulates cellular immunity and anti-bacterial defence independently of the strain of mice.
Bany J, Siwicki AK, Zdanowska D, Sokolnicka I, Skopińska-Rózewska E, Kowalczyk M. Bany J, et al. Pol J Vet Sci. 2003;6(3 Suppl):3-5. Pol J Vet Sci. 2003. PMID: 14509348 - Oral administration of freshly expressed juice of Echinacea purpurea herbs fail to stimulate the nonspecific immune response in healthy young men: results of a double-blind, placebo-controlled crossover study.
Schwarz E, Metzler J, Diedrich JP, Freudenstein J, Bode C, Bode JC. Schwarz E, et al. J Immunother. 2002 Sep-Oct;25(5):413-20. doi: 10.1097/00002371-200209000-00005. J Immunother. 2002. PMID: 12218779 Clinical Trial. - Immune system effects of echinacea, ginseng, and astragalus: a review.
Block KI, Mead MN. Block KI, et al. Integr Cancer Ther. 2003 Sep;2(3):247-67. doi: 10.1177/1534735403256419. Integr Cancer Ther. 2003. PMID: 15035888 Review.
Cited by
- The Role of Plant Extracts in Enhancing Nutrition and Health for Dogs and Cats: Safety, Benefits, and Applications.
Guo X, Wang Y, Zhu Z, Li L. Guo X, et al. Vet Sci. 2024 Sep 12;11(9):426. doi: 10.3390/vetsci11090426. Vet Sci. 2024. PMID: 39330805 Free PMC article. Review. - Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials.
Parham S, Kharazi AZ, Bakhsheshi-Rad HR, Nur H, Ismail AF, Sharif S, RamaKrishna S, Berto F. Parham S, et al. Antioxidants (Basel). 2020 Dec 21;9(12):1309. doi: 10.3390/antiox9121309. Antioxidants (Basel). 2020. PMID: 33371338 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical