A grab to move on: ER-endosome contacts in membrane protrusion formation and neurite outgrowth - PubMed (original) (raw)
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A grab to move on: ER-endosome contacts in membrane protrusion formation and neurite outgrowth
Michael Krauß et al. EMBO J. 2015.
Abstract
A key feature of many eukaryotic cells, most prominently seen in developing neurons, is their ability to form and extend membrane protrusions. How protrusion formation is linked to exocytic membrane trafficking is largely unclear. In a recent paper published in Nature, Raiborg et al identify a crucial role in this process for dynamic membrane contact sites (MCSs) between the ER and endosomes. The MCSs are formed by endoplasmic reticulum (ER)-localized protein protrudin and the late endosomal kinesin adaptor FYCO1 and the small GTPase Rab7.
Figures
Figure 1. Model for the functions of protrudin and FYCO1 in LE translocation and neurite outgrowth
ER-localized protrudin forms contact sites with late endosomes (LEs) by coincident detection of Rab7 and PI(3)P (yellow) stopping LE movement (STOP). Kinesin-1 bound to protrudin is handed over to the LE protein FYCO1, which mediates plus-end (+)-directed LE movement (MOVE) along microtubules (MT) to the periphery. Synaptotagmin 7 (SYT7)-mediated LE fusion with the plasma membrane enables protrusion formation and neurite outgrowth.
Comment on
- Repeated ER-endosome contacts promote endosome translocation and neurite outgrowth.
Raiborg C, Wenzel EM, Pedersen NM, Olsvik H, Schink KO, Schultz SW, Vietri M, Nisi V, Bucci C, Brech A, Johansen T, Stenmark H. Raiborg C, et al. Nature. 2015 Apr 9;520(7546):234-8. doi: 10.1038/nature14359. Nature. 2015. PMID: 25855459
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