High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation - PubMed (original) (raw)

Multicenter Study

doi: 10.3109/10428194.2015.1037764. Epub 2015 Aug 26.

Ariane Boumendil 2, Norbert Schmitz 2 3, Herve Finel 2, Jian J Luan 2, Gülsan Sucak 4, Didier Blaise 5, Jürgen Finke 6, Karl-Heinz Pflüger 7, Hendrik Veelken 8, Norbert-Claude Gorin 9, Xavier Poiré 10, Arnold Ganser 11, Peter Dreger 2 12, Anna Sureda 2 13

Affiliations

• PMID: 25899403
• DOI: 10.3109/10428194.2015.1037764

Multicenter Study

High-dose therapy and autologous stem cell transplantation for extra-nodal NK/T lymphoma in patients from the Western hemisphere: a study from the European Society for Blood and Marrow Transplantation

Christopher P Fox et al. Leuk Lymphoma. 2015.

Abstract

Extra-nodal NK/T lymphoma (ENKTL) is rare and more frequently encountered in East Asia. The role of high-dose therapy and autologous stem cell transplantation (HDT-ASCT) for ENKTL is unclear. Twenty-eight evaluable patients who had undergone HDT-ASCT in Europe from 2000-2009 were studied. The median age was 47 years and patients had received a median of two lines of prior therapy. Some 57% of patients were not in complete remission or beyond first complete remission at HDT-ASCT. The 1-year non-relapse mortality (NRM) was 11%; 2-year progression-free survival (PFS) and overall survival (OS) rates were 41% and 52%, respectively. Notably, the 2-year PFS and OS for those with stage III/IV disease were 33% and 40%, respectively, with no relapses beyond 1-year post-HDT-ASCT. This is the largest analysis of HDT-ASCT for patients with ENKTL reported from the Western hemisphere. Survival is comparable to East Asian cohorts and outcomes are encouraging for patients with advanced disease.

Keywords: Epstein-Barr virus; high-dose therapy; natural killer cell lymphoma; stem cell transplantation.

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