Glucagon Physiology - PubMed (original) (raw)

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Kenneth R Feingold 1, S. Faisal Ahmed 2, Bradley Anawalt 3, Marc R Blackman 4, Alison Boyce 5, George Chrousos [ 6](#full-view-book-affiliation-6 "Professor of Pediatrics and Endocrinology, Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, "Aghia Sophia" Children's Hospital, Athens, Greece"), Emiliano Corpas 7, Wouter W de Herder 8, Ketan Dhatariya 9, Kathleen Dungan 10, Johannes Hofland 11, Sanjay Kalra 12, Gregory Kaltsas 13, Nitin Kapoor 14, Christian Koch 15, Peter Kopp 16, Márta Korbonits 17, Christopher S Kovacs 18, Wendy Kuohung 19, Blandine Laferrère 20, Miles Levy 21, Elizabeth A McGee 22, Robert McLachlan 23, Radhika Muzumdar 24, Jonathan Purnell 25, Rodolfo Rey 26, Rakesh Sahay 27, Amy S Shah 28, Frederick Singer 29, Mark A Sperling 30, Constantine A Stratakis 31, Dace L Trence 32, Don P Wilson 33

, editors.

In: Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc.; 2000.

2019 Jul 16.

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Glucagon Physiology

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Excerpt

Glucagon is a peptide hormone secreted from the alpha cells of the pancreatic islets of Langerhans. Hypoglycemia is physiologically the most potent secretory stimulus and the best known action of glucagon is to stimulate glucose production in the liver and thereby to maintain adequate plasma glucose concentrations. However, glucagon is also involved in hepatic lipid and amino acid metabolism and may increase resting energy expenditure. Based on satiety-inducing and food intake-lowering effects of exogenous glucagon, a role for glucagon in the regulation of appetite has also been proposed. This chapter provides an overview of the structure, secretion, degradation and elimination of glucagon, and reviews the actions of glucagon including its role in glucose metabolism and its effects on lipolysis, ketogenesis, energy expenditure, appetite and food intake. Finally, the role of glucagon in the pathophysiology of diabetes, obesity and hepatic steatosis is discussed and emerging glucagon-based therapies for these conditions are outlined. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text, WWW.ENDOTEXT.ORG.

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References

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