Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study - PubMed (original) (raw)

Multicenter Study

doi: 10.1097/MD.0000000000000802.

Gui-Qi Zhu, Bo-Zhi Ye, Fan-Qi Kong, Zai-Xing Zheng, Hai Zou, Ke-Qing Shi, Lu Lin, Martin Braddock, Wei-Jian Huang, Yong-Ping Chen, Ming-Hua Zheng

Affiliations

Multicenter Study

Association between sex-specific serum uric acid and non-alcoholic fatty liver disease in Chinese adults: a large population-based study

Sheng-Jie Wu et al. Medicine (Baltimore). 2015 May.

Abstract

The aim of this study was to examine the association between sex-specific serum uric acid (sUA) levels and NAFLD in a large population-based study.A total of 60,455 subjects from 2 separate medical centers were included. Sex-specific sUA quartiles (Q1-Q4) were defined: ≤330, 331-380, 381-435, and ≥436 μmol/L for male; ≤230, 231-270, 271-310, and ≥311 μmol/L for female. The odds ratios (ORs), hazard ratios (HRs), and 95% confidence intervals (CIs) for NAFLD were calculated across each quartile of sUA, using the Q1 as reference.After adjusting for known confounding variables in this study, the ORs for NAFLD in the cross-sectional population were 1.211 (95% CI 1.109-1.322), 1.519 (95% CI 1.395-1.654), 1.903 (95% CI 1.748-2.072) for Q2, Q3, and Q4, respectively. In the longitudinal population, compared with the reference group, those in Q2, Q3, and Q4 had HRs of 1.127 (95% CI 0.956-1.330), 1.380 (95% CI 1.157-1.644), 1.589 (95% CI 1.310-1.927) for NAFLD, respectively. Analysis for the sex-specific subgroup showed the adjusted ORs for Q4 versus Q1 were 2.898 (95% CI 2.36-3.588) in female and 1.887 (95% CI 1.718-2.072) in male in the cross-sectional population. In the longitudinal population, the HRs for the Q4 were 2.355 (95% CI 1.702-3.259) in female and 1.249 (95% CI 0.975-1.601) in male, compared with Q1.We report that a sex-specific sUA level is independently associated with NAFLD. The association between sUA and NAFLD was significantly greater in females than in males.

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Conflict of interest statement

The authors report no conflicts of interest.

Figures

FIGURE 1

FIGURE 1

Study flow diagram. A total of 73,583 participants were enrolled initially, whereas 13,128 participants who did not meet the inclusion criteria were excluded. Finally, 60,455 individuals (49,092 in the cross-sectional population and 11,363 in the longitudinal population) were included.

FIGURE 2

FIGURE 2

Forest plots of odds ratios (ORs) (95% confidence interval [CI]) for quartiles of serum uric acid in the cross-sectional population, stratified by sex. (A) male, (B) female. Confounding variables contained age, body mass index, systolic blood pressure, fasting plasma glucose, albumin, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

FIGURE 3

FIGURE 3

Incidence of nonalcoholic fatty liver disease (NAFLD) in the longitudinal population, stratified by sex-specific quartiles of serum uric acid. (A) Incidence of NAFLD in 4851 male subjects stratified by quartiles of serum uric acid. (B) Incidence of NAFLD in 6512 female subjects stratified by quartiles of serum uric acid. (C) Incidence of NAFLD in a total of 11,636 participators stratified by sex-specific quartiles of serum uric acid.

FIGURE 4

FIGURE 4

Unadjusted and adjusted odds ratios (ORs) and hazard ratios (HRs) for nonalcoholic fatty liver disease (NAFLD). Panels A and C showed the OR and HR of serum uric acid for NAFLD in the cross-sectional population and longitudinal population, respectively. Panels B and D showed the OR and HR of serum uric acid for NAFLD in the cross-sectional population and longitudinal population, respectively, adjusted for age, body mass index, systolic blood pressure, fasting plasma glucose, albumin, alanine aminotransferase, aspartate aminotransferase, blood urea nitrogen, creatinine, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol.

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