The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation - PubMed (original) (raw)
The ontogeny of tumor-associated macrophages: a new understanding of cancer-elicited inflammation
Ruth A Franklin et al. Oncoimmunology. 2014.
Abstract
Clinical and experimental models have identified macrophages as potential targets for cancer therapy, however, the nature of macrophage differentiation and function in the context of malignant disease remain largely uncharacterized. This commentary provides the author's perspective on the recently published article "The cellular and molecular origin of tumor-associated macrophages," which demonstrated that tumor growth elicits a specific macrophage differentiation pathway.
Keywords: Notch; breast cancer; inflammation; macrophages; monocytes.
Figures
Figure 1.
Unique steady state and inflammatory monocyte differentiation occurs in diverse physiological contexts. At steady state, monocytes (Mono) differentiate into tissue-resident macrophages (MΦ) in a limited number of tissues including heart, dermis, intestine, and mammary gland. These cells have important roles in tissue homeostasis. During pathogen infection, monocytes differentiate into a number of different effector macrophage populations, which contribute to immune defense against viruses, bacteria, and protozoa. Our study in a mouse model of breast cancer determined that tumor growth elicits a third monocyte differentiation pathway into tumor-associated macrophages with immune modulatory and possible tissue remodeling functions.
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