Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study - PubMed (original) (raw)

Dietary inflammatory index and risk of lung cancer and other respiratory conditions among heavy smokers in the COSMOS screening study

Patrick Maisonneuve et al. Eur J Nutr. 2016 Apr.

Abstract

Purpose: To test whether the inflammatory potential of diet, as measured using the dietary inflammatory index (DII), is associated with risk of lung cancer or other respiratory conditions and to compare results obtained with those based on the aMED score, an established dietary index that measures adherence to the traditional Mediterranean diet.

Methods: In 4336 heavy smokers enrolled in a prospective, non-randomized lung cancer screening program, we measured participants' diets at baseline using a self-administered food frequency questionnaire from which dietary scores were calculated. Cox proportional hazards and logistic regression models were used to assess association between the dietary indices and lung cancer diagnosed during annual screening, and other respiratory outcomes that were recorded at baseline, respectively.

Results: In multivariable analysis, adjusted for baseline lung cancer risk (estimated from age, sex, smoking history, and asbestos exposure) and total energy, both DII and aMED scores were associated with dyspnoea (p trend = 0.046 and 0.02, respectively) and radiological evidence of emphysema (p trend = 0.0002 and 0.02). After mutual adjustment of the two dietary scores, only the association between DII and radiological evidence of emphysema (Q4 vs. Q1, OR 1.30, 95 % CI 1.01-1.67, p trend = 0.012) remained statistically significant. At univariate analysis, both DII and aMED were associated with lung cancer risk, but in fully adjusted multivariate analysis, only the association with aMED remained statistically significant (p trend = 0.04).

Conclusions: Among heavy smokers, a pro-inflammatory diet, as indicated by increasing DII score, is associated with dyspnoea and radiological evidence of emphysema. A traditional Mediterranean diet, which is associated with a lower DII, may lower lung cancer risk.

Keywords: Dietary inflammatory index; Dyspnoea; Emphysema; Lung cancer; Lung function; Mediterranean diet.

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Conflict of interest statement

Conflict of interest Dr. James R. Hébert owns controlling interest in Connecting Health Innovations LLC (CHI), a company planning to license the right to his invention of the dietary inflammatory index (DII) from the University of South Carolina in order to develop computer and smart phone applications for patient counseling and dietary intervention in clinical settings. Dr. Nitin Shivappa is a paid employee of CHI. The subject matter of this paper will not have any direct bearing on that work, nor has that activity exerted any influence on this project. On behalf of all other co-authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1

Fig. 1

Sequence of steps in creating the dietary inflammatory index in the COSMOS study, 2004–2005

Fig. 2

Fig. 2

Dietary inflammatory index (DII) score according to alternate Mediterranean (aMED) score in 4336 participants to the COSMOS study, 2004–2005

Fig. 3

Fig. 3

Cumulative incidence of lung cancers detected through repeated annual screening LD-CTs according to the alternate Mediterranean diet (aMED) score and the dietary inflammatory index (DII) score, COSMOS study, 2004–2005. Hazards ratios (HRs) and 95 % confidence intervals (CIs) obtained from multivariable Cox proportional hazards regression model adjusted for (1) baseline risk probability (based on age, sex, smoking duration, smoking intensity, years of smoking cessation, and asbestos exposure) and total energy, and (2) aMED and DII scores mutual adjusted. The number of participants at risk (on screening) at baseline, at 2nd, 3rd, 4th, 5th, 6th, 7th, 8th, and 9th year were, respectively, 4336, 4249, 4061, 3865, 3640, 3413, 3219, 3028, 2727, and 883

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