trans-activation by the hepatitis B virus X protein shows cell-type specificity - PubMed (original) (raw)
trans-activation by the hepatitis B virus X protein shows cell-type specificity
E Seto et al. Virology. 1989 Dec.
Abstract
The hepatitis B virus X protein can trans-activate transcription from many viral promoters. We show here that this trans-activation is cell-type but not species specific, and that only a subset of promoters is trans-activated in any particular cell type. Furthermore, the T/t-antigens from simian virus 40 suppress this trans-activation. We hypothesize that the X protein acts via cellular factors which are phylogenetically conserved and developmentally regulated and whose effects are blocked by the T/t-antigens.
Similar articles
- A trans-activator function is generated by integration of hepatitis B virus preS/S sequences in human hepatocellular carcinoma DNA.
Caselmann WH, Meyer M, Kekulé AS, Lauer U, Hofschneider PH, Koshy R. Caselmann WH, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(8):2970-4. doi: 10.1073/pnas.87.8.2970. Proc Natl Acad Sci U S A. 1990. PMID: 2158099 Free PMC article. - Effect of X protein on transactivation of hepatitis B virus promoters and on viral replication.
Nakatake H, Chisaka O, Yamamoto S, Matsubara K, Koshy R. Nakatake H, et al. Virology. 1993 Aug;195(2):305-14. doi: 10.1006/viro.1993.1381. Virology. 1993. PMID: 8337816 - Alternate translation initiation on hepatitis B virus X mRNA produces multiple polypeptides that differentially transactivate class II and III promoters.
Kwee L, Lucito R, Aufiero B, Schneider RJ. Kwee L, et al. J Virol. 1992 Jul;66(7):4382-9. doi: 10.1128/JVI.66.7.4382-4389.1992. J Virol. 1992. PMID: 1318408 Free PMC article. - [The role of X protein in the life cycle of hepatitis B virus].
Song JW, Lin JS. Song JW, et al. Zhonghua Gan Zang Bing Za Zhi. 2003 Aug;11(8):511-2. Zhonghua Gan Zang Bing Za Zhi. 2003. PMID: 12939199 Review. Chinese. No abstract available. - [Regulation of hepatitis B virus replication regulated by HBX protein].
Wang JZ, Yang DL. Wang JZ, et al. Zhonghua Gan Zang Bing Za Zhi. 2009 Oct;17(10):797-8. Zhonghua Gan Zang Bing Za Zhi. 2009. PMID: 19874703 Review. Chinese. No abstract available.
Cited by
- Identification of the hepatitis B virus factor that inhibits expression of the beta interferon gene.
Whitten TM, Quets AT, Schloemer RH. Whitten TM, et al. J Virol. 1991 Sep;65(9):4699-704. doi: 10.1128/JVI.65.9.4699-4704.1991. J Virol. 1991. PMID: 1870197 Free PMC article. - Different regions of hepatitis B virus X protein are required for enhancement of bZip-mediated transactivation versus transrepression.
Barnabas S, Andrisani OM. Barnabas S, et al. J Virol. 2000 Jan;74(1):83-90. doi: 10.1128/jvi.74.1.83-90.2000. J Virol. 2000. PMID: 10590094 Free PMC article. - The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks.
Chen HS, Kaneko S, Girones R, Anderson RW, Hornbuckle WE, Tennant BC, Cote PJ, Gerin JL, Purcell RH, Miller RH. Chen HS, et al. J Virol. 1993 Mar;67(3):1218-26. doi: 10.1128/JVI.67.3.1218-1226.1993. J Virol. 1993. PMID: 8437213 Free PMC article. - The hepatitis B virus X protein increases the cellular level of TATA-binding protein, which mediates transactivation of RNA polymerase III genes.
Wang HD, Yuh CH, Dang CV, Johnson DL. Wang HD, et al. Mol Cell Biol. 1995 Dec;15(12):6720-8. doi: 10.1128/MCB.15.12.6720. Mol Cell Biol. 1995. PMID: 8524237 Free PMC article. - Diversity of hepatitis B virus X gene-related transcripts in hepatocellular carcinoma: a novel polyadenylation site on viral DNA.
Hilger C, Velhagen I, Zentgraf H, Schröder CH. Hilger C, et al. J Virol. 1991 Aug;65(8):4284-91. doi: 10.1128/JVI.65.8.4284-4291.1991. J Virol. 1991. PMID: 1649331 Free PMC article.