MAP, an expert system for multiple pairwise linkage analysis - PubMed (original) (raw)

MAP, an expert system for multiple pairwise linkage analysis

N E Morton et al. Ann Hum Genet. 1989 Jul.

Abstract

The logic of a program for multiple pairwise linkage analysis under interference is set forth, including a seriation algorithm to obtain a trial order, a mapping bootstrap to improve the trial order, and three procedures for quality control to detect mistyping. This approach is compared with multipoint analysis under null interference, which substantially overestimates map length and cannot incorporate a variety of data.

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