EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κB - PubMed (original) (raw)

. 2015 Jul;463(1-2):95-101.

doi: 10.1016/j.bbrc.2015.05.030. Epub 2015 May 18.

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EGFR-TKI down-regulates PD-L1 in EGFR mutant NSCLC through inhibiting NF-κB

Kailong Lin et al. Biochem Biophys Res Commun. 2015 Jul.

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Abstract

Non-small-cell lung cancer (NSCLC) is a severe disease threatening human health. Targeted therapy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors (TKIs) has obtained potent efficacy in the treatment of NSCLC patients. However, the effects of EGFR-TKIs on tumor immune microenvironment are unclear. In this study, we show that NSCLCs with EGFR mutation express higher programmed cell death ligand 1 (PD-L1) than NSCLCs with wild type EGFR. The EGFR activation is also associated with high expression of PD-L1. The EGFR-TKI gefitinib can reduce PD-L1 expression, via inhibiting NF-κB, in EGFR mutant NSCLC in vitro and in vivo. These findings elucidate a novel anti-tumor mechanism of EGFR-TKI and provide the possibility of combined strategy of targeted therapy and immunotherapy for EGFR mutant NSCLC patients.

Keywords: EGFR-TKI; NF-κB; NSCLC; PD-L1.

Copyright © 2015 Elsevier Inc. All rights reserved.

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