The vascular secret of Klotho - PubMed (original) (raw)
Comment
. 2015 Jun;87(6):1089-91.
doi: 10.1038/ki.2015.80.
Affiliations
- PMID: 26024025
- DOI: 10.1038/ki.2015.80
Free article
Comment
The vascular secret of Klotho
Ewa Lewin et al. Kidney Int. 2015 Jun.
Free article
Abstract
Klotho is an evolutionarily highly conserved protein related to longevity. Increasing evidence of a vascular protecting effect of the Klotho protein has emerged and might be important for future treatments of uremic vascular calcification. It is still disputed whether Klotho is locally expressed in the vasculature or whether its vascular effects arise uniquely from its presence in the circulation.
Comment on
- Differential expression and regulation of Klotho by paricalcitol in the kidney, parathyroid, and aorta of uremic rats.
Ritter CS, Zhang S, Delmez J, Finch JL, Slatopolsky E. Ritter CS, et al. Kidney Int. 2015 Jun;87(6):1141-52. doi: 10.1038/ki.2015.22. Epub 2015 Feb 18. Kidney Int. 2015. PMID: 25692955 Free PMC article.