Anthropometry and head and neck cancer:a pooled analysis of cohort data - PubMed (original) (raw)

doi: 10.1093/ije/dyv059. Epub 2015 Jun 6.

Cari M Kitahara 1, Christina C Newton 1, Leslie Bernstein 1, Peggy Reynolds 1, Elisabete Weiderpass 1, Aimée R Kreimer 1, Gong Yang 1, Hans-Olov Adami 1, Michael C Alavanja 1, Laura E Beane Freeman 1, Heiner Boeing 1, Julie Buring 1, Anil Chaturvedi 1, Yu Chen 1, Aimee A D'Aloisio 1, Michal Freedman 1, Yu-Tang Gao 1, J Michael Gaziano 1, Graham G Giles 1, Niclas Håkansson 1, Wen-Yi Huang 1, I-Min Lee 1, Martha S Linet 1, Robert J MacInnis 1, Yikyung Park 1, Anna Prizment 1, Mark P Purdue 1, Elio Riboli 1, Kim Robien 1, Dale P Sandler 1, Catherine Schairer 1, Howard D Sesso 1, Xiao Ou Shu 1, Emily White 1, Alicja Wolk 1, Yong-Bing Xiang 1, Anne Zelenuich-Jacquotte 1, Wei Zheng 1, Alpa V Patel 1, Patricia Hartge 1, Amy Berrington de González 1, Susan M Gapstur 1

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Anthropometry and head and neck cancer:a pooled analysis of cohort data

Mia M Gaudet et al. Int J Epidemiol. 2015 Apr.

Abstract

Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies.

Methods: We pooled data from 1,941,300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status.

Results: Greater waist circumference (per 5 cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = <0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.09, P-value for trend = <0.0001), adjusted for body mass index (BMI), were associated with higher risk and did not vary by smoking status (P-value for heterogeneity = 0.85 and 0.44, respectively). Associations with BMI (P-value for interaction = <0.0001) varied by smoking status. Larger BMI was associated with higher HNC risk in never smokers (per 5 kg/m(2): HR = 1.15, 95% CI 1.06-1.24, P-value for trend = 0.0006), but not in former smokers (per 5 kg/m(2): HR = 0.99, 95% CI 0.93-1.06, P-value for trend = 0.79) or current smokers (per 5 kg/m(2): HR = 0.76, 95% CI 0.71-0.82, P-value for trend = <0.0001). Larger hip circumference was not associated with a higher HNC risk. Greater height (per 5 cm) was associated with higher risk of HNC in never and former smokers, but not in current smokers.

Conclusions: Waist circumference and waist-to-hip ratio were associated positively with HNC risk regardless of smoking status, whereas a positive association with BMI was only found in never smokers.

Keywords: Head and neck neoplasms; obesity; smoking; waist circumference; waist-hip ratio.

© The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.

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