Issues relating to study design and risk of bias when including non-randomized studies in systematic reviews on the effects of interventions - PubMed (original) (raw)
doi: 10.1002/jrsm.1056. Epub 2012 Sep 25.
Affiliations
- PMID: 26053536
- DOI: 10.1002/jrsm.1056
Issues relating to study design and risk of bias when including non-randomized studies in systematic reviews on the effects of interventions
Julian Pt Higgins et al. Res Synth Methods. 2013 Mar.
Erratum in
- Special issue on inclusion of non-randomized studies in systematic reviews.
Reeves BC, Wells GA. Reeves BC, et al. Res Synth Methods. 2013 Sep;4(3):287-9. doi: 10.1002/jrsm.1089. Epub 2013 Aug 7. Res Synth Methods. 2013. PMID: 26053846 No abstract available.
Abstract
Non-randomized studies may provide valuable evidence on the effects of interventions. They are the main source of evidence on the intended effects of some types of interventions and often provide the only evidence about the effects of interventions on long-term outcomes, rare events or adverse effects. Therefore, systematic reviews on the effects of interventions may include various types of non-randomized studies. In this second paper in a series, we address how review authors might articulate the particular non-randomized study designs they will include and how they might evaluate, in general terms, the extent to which a particular non-randomized study is at risk of important biases. We offer guidance for describing and classifying different non-randomized designs based on specific features of the studies in place of using non-informative study design labels. We also suggest criteria to consider when deciding whether to include non-randomized studies. We conclude that a taxonomy of study designs based on study design features is needed. Review authors need new tools specifically to assess the risk of bias for some non-randomized designs that involve a different inferential logic compared with parallel group trials. Copyright © 2012 John Wiley & Sons, Ltd.
Keywords: bias; non-randomized studies; study design; systematic reviews.
Copyright © 2012 John Wiley & Sons, Ltd.
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