Nonalcoholic fatty liver disease prevalence in urban school-aged children and adolescents from the Yangtze River delta region: a cross-sectional study - PubMed (original) (raw)

Nonalcoholic fatty liver disease prevalence in urban school-aged children and adolescents from the Yangtze River delta region: a cross-sectional study

Xiaomin Zhang et al. Asia Pac J Clin Nutr. 2015.

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Abstract

in English, Chinese

Purpose: To determine the prevalence of nonalcoholic fatty liver disease (NAFLD) and explore the relationship of NAFLD with anthropometric parameters among school children from the Yangtze River delta region.

Methods: A cross sectional study on childhood NAFLD was conducted using the stratified cluster sampling method in four regions of the Yangtze River delta in September 2009 to October 2011. In all, 7,229 students, aged 7-18 years, from 12 primary, middle and high schools participated in the study. Height, weight, and waist circumference were measured; body mass index (BMI) and waist to height ratio (WHtR) were calculated and liver ultrasonography was performed.

Results: The overall NAFLD prevalence was 5.0%; 7.5% in boys, 2.5% in girls, 5.6% in subjects with peripheral obesity, 12.9% in those with abdominal obesity and 44.8% in those with mixed obesity. The prevalence was also increased with regional difference. Binary logistic regression analysis showed that WHtR was the major independent risk factor for childhood NAFLD, causing a 14.4-fold increase in NAFLD risk. Receiver operating characteristic curve analysis also showed that WHtR was the best obesity index to evaluate the presence of NAFLD in Chinese schoolchildren with the optimal cutoff of 0.47.

Conclusions: Mixed obesity had the strongest association with NAFLD. Male gender and regional urbanization also influenced NAFLD prevalence among schoolchildren. WHtR may be an effective indicator to predict NAFLD.

目的：调查中国长三角地区在校学生儿童非酒精性脂肪肝发生率及其与体格指 标之间的关系。方法：2009年9月至2011年10月，长三角地区分层抽取4个城 市，12所中小学，7229名7-18岁在校学生纳入本次调查。所有研究对象均测量 身高、体重、腰围、计算腰围身高比和体重指数，并进行肝脏超声检查。结 果：调查显示该地区在校学生儿童非酒精性脂肪肝总发生率为5%，其中男生 7.5%，女生2.5%。非酒精性脂肪肝在外周型肥胖，腹型肥胖及混合型肥胖人群 中的发生率分别为5.6%，12.9%，44.8%。4所城市在校学生儿童非酒精性脂肪 肝发生率也有不同。二元logistic回归分析显示腰围身高比是儿童非酒精性脂肪 肝的主要危险因素，每升高0.1，患病风险增加14.4倍。ROC分析显示，腰围身 高比同样是该病的最佳预测体格指标，适宜切点值在0.47。结论：混合型肥胖 与儿童非酒精性脂肪肝密切相关。男性，地区等因素同样影响该病在儿童青少 年群体中的发生。腰围身高比能有效预测非酒精性脂肪肝的发生。.

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