Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment - PubMed (original) (raw)

Meta-Analysis

Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment

Liang Shen et al. Nutrients. 2015.

Abstract

The present study aimed to quantitatively assess the associations between vitamin D and Parkinson's Disease (PD) risks, which include: (i) risk of PD in subjects with deficient and insufficient vitamin D levels; (ii) association between vitamin D supplementation and risk of PD; and (iii) association between outdoor work and PD risk, through meta-analyzing available data. An electronic literature search supplemented by hand searching up to March 2015 identified seven eligible studies comprising 5690 PD patients and 21251 matched controls. Odds ratio (OR) and 95% confidence interval (CI) of PD risk were assessed through pooling the collected data from eligible studies using Stata software. Pooled data showed that subjects with deficient and insufficient vitamin D levels had increased PD risks compared with matched-controls according to the corresponding OR: 2.08, 95% CI: 1.63 to 2.65, and 1.29, 95% CI: 1.10 to 1.51. Vitamin D supplementation was associated with significantly reduced risk of PD (OR: 0.62, 95% CI: 0.35 to 0.90). Outdoor work was also related to reduced risk of PD (OR: 0.72, 95% CI: 0.63 to 0.81). The findings may stimulate larger, well-designed studies to further verify the associations between vitamin D and PD risk.

Keywords: Parkinson’s disease; meta-analysis; outdoor work; vitamin D.

PubMed Disclaimer

Figures

Figure 1

Flow diagram of literature search and identification of relevant studies.

Figure 2

Forest plots of deficient and insufficient vitamin D levels and risk of Parkinson’s Disease (PD).

Figure 3

Forest plots of vitamin D supplementation and risk of PD.

Figure 4

Forest plots of outdoor work and risk of PD.

Cited by

Nutraceuticals Targeting Generation and Oxidant Activity of Peroxynitrite May Aid Prevention and Control of Parkinson's Disease.
McCarty MF, Lerner A. McCarty MF, et al. Int J Mol Sci. 2020 May 21;21(10):3624. doi: 10.3390/ijms21103624. Int J Mol Sci. 2020. PMID: 32455532 Free PMC article. Review.
Foods for Special Medical Purposes in Home Enteral Nutrition-Clinical Practice Experience. Multicenter Study.
Folwarski M, Kłęk S, Zoubek-Wójcik A, Szafrański W, Bartoszewska L, Figuła K, Jakubczyk M, Jurczuk A, Kamocki Z, Kowalczyk T, Kwella B, Matras P, Sonsala-Wołczyk J, Szopiński J, Urbanowicz K, Zmarzły A. Folwarski M, et al. Front Nutr. 2022 Jul 7;9:906186. doi: 10.3389/fnut.2022.906186. eCollection 2022. Front Nutr. 2022. PMID: 35873447 Free PMC article.
Association between Circulating Vitamin D Level and Urolithiasis: A Systematic Review and Meta-Analysis.
Hu H, Zhang J, Lu Y, Zhang Z, Qin B, Gao H, Wang Y, Zhu J, Wang Q, Zhu Y, Xun Y, Wang S. Hu H, et al. Nutrients. 2017 Mar 18;9(3):301. doi: 10.3390/nu9030301. Nutrients. 2017. PMID: 28335477 Free PMC article.
Vitamin D in amyotrophic lateral sclerosis.
Libonati L, Onesti E, Gori MC, Ceccanti M, Cambieri C, Fabbri A, Frasca V, Inghilleri M. Libonati L, et al. Funct Neurol. 2017 Jan/Mar;32(1):35-40. doi: 10.11138/fneur/2017.32.1.035. Funct Neurol. 2017. PMID: 28380322 Free PMC article.
Association of time spent outdoors with the risk of Parkinson's disease: a prospective cohort study of 329,359 participants.
Hu L, Shi Y, Zou X, Lai Z, Lin F, Cai G, Liu X. Hu L, et al. BMC Neurol. 2024 Jan 2;24(1):10. doi: 10.1186/s12883-023-03499-7. BMC Neurol. 2024. PMID: 38166701 Free PMC article.

References

1. Gröber U., Spitz J., Reichrath J., Kisters K., Holick M.F. Vitamin D: Update 2013: From rickets prophylaxis to general preventive healthcare. Dermatoendocrinology. 2013;5:331–347. doi: 10.4161/derm.26738. - DOI - PMC - PubMed
1. Vacek J.L., Vanga S.R., Good M., Lai S.M., Lakkireddy D., Howard P.A. Vitamin D deficiency and supplementation and relation to cardiovascular health. Am. J. Cardiol. 2012;109:359–363. doi: 10.1016/j.amjcard.2011.09.020. - DOI - PubMed
1. Wacker M., Holick M.F. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinology. 2013;5:51–108. doi: 10.4161/derm.24494. - DOI - PMC - PubMed
1. Bolland M.J., Grey A., Gamble G.D., Reid I.R. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: A trial sequential meta-analysis. Lancet Diabetes Endocrinol. 2014;2:307–320. doi: 10.1016/S2213-8587(13)70212-2. - DOI - PubMed
1. Garcion E., Wion-Barbot N., Montero-Menei C.N., Berger F., Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol. Metab. 2002;13:100–105. doi: 10.1016/S1043-2760(01)00547-1. - DOI - PubMed

Associations between Vitamin D Status, Supplementation, Outdoor Work and Risk of Parkinson's Disease: A Meta-Analysis Assessment - PubMed (original) (raw)