Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family - PubMed (original) (raw)

Comparative Study

. 1989 Dec 29;165(3):1198-206.

doi: 10.1016/0006-291x(89)92729-0.

Affiliations

• PMID: 2610687
• DOI: 10.1016/0006-291x(89)92729-0

Comparative Study

Vascular endothelial growth factor: a new member of the platelet-derived growth factor gene family

E Tischer et al. Biochem Biophys Res Commun. 1989.

Abstract

Using applications of the polymerase chain reaction (PCR) technique, cDNA clones have been isolated encoding bovine vascular endothelial growth factor (VEGF), a mitogen with specificity for vascular endothelial cells. Analysis of the clones indicates that VEGF can exist in two forms, probably due to alternative RNA splicing. The amino acid sequences predicted from the clones also show that VEGF shares homologies of about 21% and 24% respectively with the A and B chains of human platelet-derived growth factor (PDGF), and has complete conservation of the eight cysteine residues found in both mature PDGF chains. The homology is not reflected in function, however, since the cell types responsive to VEGF are distinct from those responsive to homo- and heterodimers of the PDGF chains.

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