Liver mitochondrial respiratory functions decline with age - PubMed (original) (raw)
Comparative Study
. 1989 Dec 29;165(3):944-1003.
doi: 10.1016/0006-291x(89)92701-0.
Affiliations
- PMID: 2610701
- DOI: 10.1016/0006-291x(89)92701-0
Comparative Study
Liver mitochondrial respiratory functions decline with age
T C Yen et al. Biochem Biophys Res Commun. 1989.
Abstract
Human liver mitochondrial respiration rates in Chinese populations of various ages were assayed with an oxygraph. In this study, State 3 and State 4 respiration rates, respiratory control ratio (RCR), and ADP/O ratio were measured for 35 Chinese subjects of 31 to 76 years old. We found a significant negative correlation between age and respiratory control and ADP/O ratios tested. Moreover, the respiratory control and ADP/O ratios decreased with the increase of age. These findings suggest that a substantial fall in mitochondrial oxidative capacity in ageing liver may be an important contributor to the ageing process.
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