Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies - PubMed (original) (raw)
Meta-Analysis
. 2015 Aug;145(8):1763-9.
doi: 10.3945/jn.115.213074. Epub 2015 Jun 24.
Affiliations
- PMID: 26108545
- PMCID: PMC4516773
- DOI: 10.3945/jn.115.213074
Meta-Analysis
Zinc Absorption Is Not Related to Dietary Phytate Intake in Infants and Young Children Based on Modeling Combined Data from Multiple Studies
Leland V Miller et al. J Nutr. 2015 Aug.
Abstract
Background: It is widely understood that the 2 primary factors affecting dietary zinc absorption in adults are the quantities of zinc and phytate in the diet. Although a similar association of absorption to dietary zinc and phytate is presumed to exist in children, to our knowledge, no large-scale examination of the relation of zinc absorption to dietary and growth factors has been conducted.
Objective: The goal was to apply an adult absorption model and related models to data from zinc absorption studies of infants and children in order to determine the nature of the relation of zinc absorption to dietary zinc and phytate, age, body size, and zinc homeostatic variables.
Methods: Data from 236 children between 8 and 50 mo of age were obtained from stable-isotope studies of zinc absorption. Statistical and mechanistic models were fit to the data using linear and nonlinear regression analysis.
Results: The effect of dietary phytate on zinc absorption when controlling for dietary zinc was very small and not statistically discernable (P = 0.29). A 500-mg/d increase in dietary phytate reduced absorbed zinc by <0.04 mg/d. Absorption was observed to vary with age, weight, and height (P < 0.0001) when controlling for dietary zinc. For example, absorption from 6 mg/d of dietary zinc increased by as much as 0.2 mg/d with a 12-mo increase in age. Absorption varied with weight and exchangeable zinc pool size (0.01 < P < 0.05) when controlling for dietary zinc and age.
Conclusions: The absence of a detectable phytate effect on zinc absorption raises caution about use of dietary phytate:zinc molar ratios to predict zinc bioavailability and does not support phytate reduction as a strategy to improve zinc status of young children. The effect of age on zinc absorption and the absence of a phytate effect should facilitate estimations of dietary zinc needs in young children.
Keywords: dietary phytate; dietary zinc; infants; mathematical modeling; young children; zinc absorption.
© 2015 American Society for Nutrition.
Conflict of interest statement
Author disclosures: LV Miller, KM Hambidge, and NF Krebs, no conflicts of interest.
Figures
FIGURE 1
The relation of daily absorbed zinc to dietary zinc and phytate intake in infants and young children. The surface represents the absorption response predicted by the Equation 1 model fitted to the infant/child data having TDPA values (n = 172). The vertical lines from each datum to the surface show the residual, i.e., the deviation of the point from the model’s prediction. Although an increase in absorption with increasing zinc intake is evident, there is only the suggestion of an inhibiting effect of phytate in the small downward slope of the surface with increasing phytate intake (most evident at the right side). TDPA, total daily dietary phytate (phytic acid).
FIGURE 2
The relation of daily absorbed zinc to dietary zinc and phytate intake in infants and young children. This is a 2-dimensional version of Figure 1 showing the absorption response to dietary zinc intake for selected quantities of dietary phytate. The predicted response curves for corresponding intakes from the adult model (3) are shown for comparison of the phytate effect. The difference in the magnitude of the phytate effect is evident. TDPA, total daily dietary phytate (phytic acid).
FIGURE 3
The relation of daily absorbed zinc to dietary zinc and age in infants and young children. The surface represents the absorption response predicted by the Equation 2 model fitted to all the child data (n = 233). An increase in absorption with dietary zinc or age is evident.
FIGURE 4
The relation of daily absorbed zinc to dietary zinc and age in infants and young children. This is a 2-dimensional version of Figure 3 showing the absorption response to dietary zinc intake for selected age groups. TDZ, total daily dietary zinc.
Similar articles
- Dietary phytate reduction improves zinc absorption in Malawian children recovering from tuberculosis but not in well children.
Manary MJ, Hotz C, Krebs NF, Gibson RS, Westcott JE, Arnold T, Broadhead RL, Hambidge KM. Manary MJ, et al. J Nutr. 2000 Dec;130(12):2959-64. doi: 10.1093/jn/130.12.2959. J Nutr. 2000. PMID: 11110854 Clinical Trial. - The zinc nutriture of preschool children living in two African countries.
Ferguson EL, Gibson RS, Opare-Obisaw C, Ounpuu S, Thompson LU, Lehrfeld J. Ferguson EL, et al. J Nutr. 1993 Sep;123(9):1487-96. doi: 10.1093/jn/123.9.1487. J Nutr. 1993. PMID: 8395593 - Upregulation of Zinc Absorption Matches Increases in Physiologic Requirements for Zinc in Women Consuming High- or Moderate-Phytate Diets during Late Pregnancy and Early Lactation.
Hambidge KM, Miller LV, Mazariegos M, Westcott J, Solomons NW, Raboy V, Kemp JF, Das A, Goco N, Hartwell T, Wright L, Krebs NF. Hambidge KM, et al. J Nutr. 2017 Jun;147(6):1079-1085. doi: 10.3945/jn.116.245902. Epub 2017 Apr 19. J Nutr. 2017. PMID: 28424260 Free PMC article. Clinical Trial. - Absorption studies show that phytase from Aspergillus niger significantly increases iron and zinc bioavailability from phytate-rich foods.
Troesch B, Jing H, Laillou A, Fowler A. Troesch B, et al. Food Nutr Bull. 2013 Jun;34(2 Suppl):S90-101. doi: 10.1177/15648265130342S111. Food Nutr Bull. 2013. PMID: 24050000 Review. - A review of phytate, iron, zinc, and calcium concentrations in plant-based complementary foods used in low-income countries and implications for bioavailability.
Gibson RS, Bailey KB, Gibbs M, Ferguson EL. Gibson RS, et al. Food Nutr Bull. 2010 Jun;31(2 Suppl):S134-46. doi: 10.1177/15648265100312S206. Food Nutr Bull. 2010. PMID: 20715598 Review.
Cited by
- Phytate Intake, Health and Disease: "Let Thy Food Be Thy Medicine and Medicine Be Thy Food".
Pujol A, Sanchis P, Grases F, Masmiquel L. Pujol A, et al. Antioxidants (Basel). 2023 Jan 7;12(1):146. doi: 10.3390/antiox12010146. Antioxidants (Basel). 2023. PMID: 36671007 Free PMC article. Review. - Toward revising dietary zinc recommendations for children aged 0 to 3 years: a systematic review and meta-analysis of zinc absorption, excretion, and requirements for growth.
Ceballos-Rasgado M, Lowe NM, Moran VH, Clegg A, Mallard S, Harris C, Montez J, Xipsiti M. Ceballos-Rasgado M, et al. Nutr Rev. 2023 Jul 10;81(8):967-987. doi: 10.1093/nutrit/nuac098. Nutr Rev. 2023. PMID: 36478064 Free PMC article. - Zinc Fortification: Current Trends and Strategies.
Hall AG, King JC. Hall AG, et al. Nutrients. 2022 Sep 21;14(19):3895. doi: 10.3390/nu14193895. Nutrients. 2022. PMID: 36235548 Free PMC article. Review. - Nutritional compositions and bioactive compounds of "Shameta", A traditional home made fermented porridge provided exclusively to lactating mothers in the western part of Ethiopia.
Kitessa DA, Bacha K, Tola YB, Murimi M, Smith E, Gershe S. Kitessa DA, et al. Heliyon. 2022 Feb 17;8(2):e08990. doi: 10.1016/j.heliyon.2022.e08990. eCollection 2022 Feb. Heliyon. 2022. PMID: 35243103 Free PMC article.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources