Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane - PubMed (original) (raw)
Review
Establishment of NE asymmetry—targeting of membrane proteins to the inner nuclear membrane
Rosemarie Ungricht et al. Curr Opin Cell Biol. 2015 Jun.
Abstract
The inner nuclear membrane (INM) represents a specialized subdomain of the endoplasmic reticulum (ER). The INM houses a unique set of integral membrane proteins that perform key functions in the organization of intranuclear architecture, control of gene expression and coupling of the nucleus to the cytoskeleton. However, the molecular mechanism of membrane protein sorting from the ER to the INM has remained enigmatic. Recently, novel approaches combining visual kinetic assays and computational modeling were used to define the requirements of trafficking to the INM in human cells. These studies reveal that nuclear retention, diffusional mobility in the ER as well as the number and architecture of NPCs are major determinants of INM targeting, collectively lending support to a diffusion-retention-based mechanism.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Similar articles
- Efficient protein targeting to the inner nuclear membrane requires Atlastin-dependent maintenance of ER topology.
Pawar S, Ungricht R, Tiefenboeck P, Leroux JC, Kutay U. Pawar S, et al. Elife. 2017 Aug 14;6:e28202. doi: 10.7554/eLife.28202. Elife. 2017. PMID: 28826471 Free PMC article. - Live imaging and modeling of inner nuclear membrane targeting reveals its molecular requirements in mammalian cells.
Boni A, Politi AZ, Strnad P, Xiang W, Hossain MJ, Ellenberg J. Boni A, et al. J Cell Biol. 2015 Jun 8;209(5):705-20. doi: 10.1083/jcb.201409133. J Cell Biol. 2015. PMID: 26056140 Free PMC article. - Diffusion and retention are major determinants of protein targeting to the inner nuclear membrane.
Ungricht R, Klann M, Horvath P, Kutay U. Ungricht R, et al. J Cell Biol. 2015 Jun 8;209(5):687-703. doi: 10.1083/jcb.201409127. J Cell Biol. 2015. PMID: 26056139 Free PMC article. - The Diverse Cellular Functions of Inner Nuclear Membrane Proteins.
Pawar S, Kutay U. Pawar S, et al. Cold Spring Harb Perspect Biol. 2021 Sep 1;13(9):a040477. doi: 10.1101/cshperspect.a040477. Cold Spring Harb Perspect Biol. 2021. PMID: 33753404 Free PMC article. Review. - Patrolling the nucleus: inner nuclear membrane-associated degradation.
Smoyer CJ, Jaspersen SL. Smoyer CJ, et al. Curr Genet. 2019 Oct;65(5):1099-1106. doi: 10.1007/s00294-019-00971-1. Epub 2019 Apr 24. Curr Genet. 2019. PMID: 31020383 Free PMC article. Review.
Cited by
- Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state.
Borah S, Thaller DJ, Hakhverdyan Z, Rodriguez EC, Isenhour AW, Rout MP, King MC, Lusk CP. Borah S, et al. Mol Biol Cell. 2021 Jul 15;32(15):1359-1373. doi: 10.1091/mbc.E20-09-0584. Epub 2021 May 19. Mol Biol Cell. 2021. PMID: 34010011 Free PMC article. - Methodologies to monitor protein turnover at the inner nuclear membrane.
Tsai PL, Zhao C, Schlieker C. Tsai PL, et al. Methods Enzymol. 2019;619:47-69. doi: 10.1016/bs.mie.2018.12.033. Epub 2019 Feb 8. Methods Enzymol. 2019. PMID: 30910029 Free PMC article. - Torsin ATPases influence chromatin interaction of the Torsin regulator LAP1.
Luithle N, de Bos JU, Hovius R, Maslennikova D, Lewis RT, Ungricht R, Fierz B, Kutay U. Luithle N, et al. Elife. 2020 Dec 15;9:e63614. doi: 10.7554/eLife.63614. Elife. 2020. PMID: 33320087 Free PMC article. - Sculpting nuclear envelope identity from the endoplasmic reticulum during the cell cycle.
Deolal P, Scholz J, Ren K, Bragulat-Teixidor H, Otsuka S. Deolal P, et al. Nucleus. 2024 Dec;15(1):2299632. doi: 10.1080/19491034.2023.2299632. Epub 2024 Jan 18. Nucleus. 2024. PMID: 38238284 Free PMC article. Review. - The cellular environment shapes the nuclear pore complex architecture.
Schuller AP, Wojtynek M, Mankus D, Tatli M, Kronenberg-Tenga R, Regmi SG, Dip PV, Lytton-Jean AKR, Brignole EJ, Dasso M, Weis K, Medalia O, Schwartz TU. Schuller AP, et al. Nature. 2021 Oct;598(7882):667-671. doi: 10.1038/s41586-021-03985-3. Epub 2021 Oct 13. Nature. 2021. PMID: 34646014 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources