High circulating microRNA-122 expression is a poor prognostic marker in patients with hepatitis B virus-related hepatocellular carcinoma who undergo radiofrequency ablation - PubMed (original) (raw)

. 2015 Nov;48(16-17):1073-8.

doi: 10.1016/j.clinbiochem.2015.06.019. Epub 2015 Jun 27.

Jai Keun Kim 2, Ji Sun Nam 3, Hee Jung Wang 4, Jei Hee Lee 2, Bong Wan Kim 4, Soon Sun Kim 1, Choong Kyun Noh 1, Sung Jae Shin 1, Kee Myung Lee 1, Sung Won Cho 1, Jae Youn Cheong 5

Affiliations

Hyo Jung Cho et al. Clin Biochem. 2015 Nov.

Abstract

Objectives: Aim of this study was to investigate the prognostic potential of plasma microRNA-122 levels in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma after hepatic resection or radiofrequency ablation (RFA).

Design and methods: A total of 120 patients with HBV-related hepatocellular carcinoma who underwent hepatic resection (n=63) or RFA (n=57) were included. The pretreatment plasma microRNA-122 level was assessed using quantitative real time polymerase chain reaction, and the correlation between microRNA-122 expression and various clinical parameters was investigated.

Results: Multivariate Cox regression analysis demonstrated that, in all patients, a low platelet count (<100×10(9)/L), low albumin level (≤3.5g/dL.), and advanced tumor stage (modified Union for International Cancer Control stage III/IV) were independent prognostic factors for disease-free survival, while a low albumin level and advanced tumor stage were independent prognostic factors for overall survival (OS). In a subgroup analysis of patients who underwent RFA, the patients with high miR-122 expression (>100) had significantly lower OS on Kaplan-Meier analysis (P=0.042). Furthermore, high microRNA-122 expression (hazard ratio [HR]=2.67; 95% confidence interval [CI]=1.12-6.35; P=0.026) and advanced tumor stage (HR=2.27; 95% CI=1.23-4.18; P=0.009) were independent risk factors for poor OS in patients treated with RFA. The combination of microRNA-122 and tumor stage resulted in an area under the curve of 0.818 for predicting 1-year OS in patients who underwent RFA.

Conclusions: High plasma microRNA-122 expression was associated with poor OS in patients with HBV-related hepatocellular carcinoma who underwent RFA.

Keywords: Hepatocellular carcinoma; MicroRNA-122; Prognosis; Radiofrequency ablation.

Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

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