The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression - PubMed (original) (raw)

The mutually regulatory loop of epithelial-mesenchymal transition and immunosuppression in cancer progression

Limo Chen et al. Oncoimmunology. 2015.

Abstract

Epithelial-mesenchymal transition and immunosuppression are crucial for cancer metastasis and treatment resistance. The mechanism by which these distinct processes are co-opted remains incompletely understood. Our recent work has exposed the "dirty affairs" of the 2 at the tumor site, thus calling for a combined therapy to break such a dangerous liaison.

Keywords: epithelial–mesenchymal transition; immunosuppression; miRNA; therapy resistance; tumor microenvironment.

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Figures

Figure 1.

Dangerous liaison between epithelial–mesenchymal transition and immunosuppression. The microRNA-200–ZEB1 axis instigates the interplay between cancer cells and immune cells in the tumor microenvironment.

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References

1. 1. Radvanyi L. Immunotherapy exposes cancer stem cell resistance and a new synthetic lethality. Mol Ther 2013; 21:1472–4; PMID:; http://dx.doi.org/10.1038/mt.2013.160 - DOI - PMC - PubMed
2. 1. Shintani Y, Okimura A, Sato K, Nakagiri T, Kadota Y, Inoue M, Sawabata N, Minami M, Ikeda N, Kawahara K, et al.. Epithelial to mesenchymal transition is a determinant of sensitivity to chemoradiotherapy in non-small cell lung cancer. Ann Thorac Surg 2011; 92:1794–804; discussion 1804; PMID:; http://dx.doi.org/10.1016/j.athoracsur.2011.07.032 - DOI - PubMed
3. 1. Li T, Zeng ZC, Wang L, Qiu SJ, Zhou JW, Zhi XT, Yu HH, Tang ZY. Radiation enhances long-term metastasis potential of residual hepatocellular carcinoma in nude mice through TMPRSS4-induced epithelial-mesenchymal transition. Cancer Gene Ther 2011; 18:617–26; PMID:; http://dx.doi.org/10.1038/cgt.2011.29 - DOI - PubMed
4. 1. Chen L, Gibbons DL, Goswami S, Cortez MA, Ahn YH, Byers LA, Zhang X, Yi X, Dwyer D, Lin W, et al.. Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression. Nat Commun 2014; 5:5241; PMID:; http://dx.doi.org/10.1038/ncomms6241. - DOI - PMC - PubMed
5. 1. Gibbons DL, Lin W, Creighton CJ, Rizvi ZH, Gregory PA, Goodall GJ, Thilaganathan N, Du L, Zhang Y, Pertsemlidis A, et al.. Contextual extracellular cues promote tumor cell EMT and metastasis by regulating miR-200 family expression. Genes Dev 2009; 23:2140–51; PMID:; http://dx.doi.org/10.1101/gad.1820209 - DOI - PMC - PubMed

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