[Screening of pulmonary hypertension in a Spanish cohort of patients with systemic sclerosis] - PubMed (original) (raw)
Clinical Trial
doi: 10.1016/j.medcli.2015.04.029. Epub 2015 Jul 10.
[Article in Spanish]
Affiliations
- PMID: 26169331
- DOI: 10.1016/j.medcli.2015.04.029
Clinical Trial
[Screening of pulmonary hypertension in a Spanish cohort of patients with systemic sclerosis]
[Article in Spanish]
Francisco José García Hernández et al. Med Clin (Barc). 2016.
Abstract
Background and objective: Pulmonary arterial hypertension (PAH) is an important cause of morbimortality in systemic sclerosis (SSc). Evolution is worse than that of subjects with idiopathic PAH, but prognosis improves when PAH is diagnosed early. The aim of this research is to describe results of a screening program for diagnosis of pulmonary hypertension (PH) carried out in a cohort of Spanish patients with SSc.
Patients and method: PH screening was performed by transthoracic doppler echocardiography (TTDE) in 184 patients with SSc. Patients with systolic pulmonary arterial pressure estimated by TTDE>35 mmHg were evaluated per protocol to confirm diagnosis and type of PH.
Results: PAH was diagnosed in 25 patients (13.6%). Patients with diffuse and limited SSc developed PAH in a similar degree, 9/60 (15%) vs. 16/100 (16%), with no cases among patients with SSc "sine scleroderma" or "pre-scleroderma" (P<.001). The only clinical or epidemiological data characterizing patients with PAH were older age (mean age 67 years for patients with PAH vs. 56 years for those without PAH, P=.007), limited SSc, a trend toward shorter evolution of the underlying disease (median 8 years for patients with PAH vs. 10 years for those without PAH, P=.73), and a higher frequency of positive anticentromere antibodies (16 patients [64%] with PAH vs. 70 (48,3%) without PAH, P=.19).
Conclusions: Prevalence of PAH in SSc was high and supports the implementation of a regular screening program.
Keywords: Cribado; Esclerosis sistémica; Hipertensión pulmonar; Pulmonary hypertension; Screening; Systemic sclerosis.
Copyright © 2015 Elsevier España, S.L.U. All rights reserved.
Comment in
- [Pulmonary hypertension in scleroderma].
Fonollosa-Pla V, Simeón-Aznar CP. Fonollosa-Pla V, et al. Med Clin (Barc). 2016 Jan 1;146(1):21-3. doi: 10.1016/j.medcli.2015.07.002. Epub 2015 Sep 3. Med Clin (Barc). 2016. PMID: 26343153 Spanish. No abstract available. - [Stress echocardiogram in the early diagnosis of systemic sclerosis-associated pulmonary hypertension].
Callejas Rubio JL, Parra Rosado P, Ortego Centeno N. Callejas Rubio JL, et al. Med Clin (Barc). 2016 Jul 15;147(2):91. doi: 10.1016/j.medcli.2016.02.019. Epub 2016 Mar 28. Med Clin (Barc). 2016. PMID: 27033435 Spanish. No abstract available.
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