Endothelial progenitor cells accelerate the resolution of deep vein thrombosis - PubMed (original) (raw)
Review
Endothelial progenitor cells accelerate the resolution of deep vein thrombosis
Wen-Dong Li et al. Vascul Pharmacol. 2016 Aug.
Abstract
Deep vein thrombosis (DVT) causes high morbidity and mortality. Successful resolution of DVT-related thrombi is the key point in the treatment of DVT. Recently, endothelial progenitor cells (EPCs) which are multipotent progenitor cells mainly residing in human bone marrow have emerged as a promising therapeutic choice for DVT-related thrombus resolution. In this review, we discussed the mobilization and homing property of EPCs into the sites of thrombosis, mechanisms of EPCs in DVT-related thrombus resolution from the aspects of promoting endothelial regeneration, revascularization, vasoactive and angiogenic factor secretion, proteinase generation, thrombus propagation and recurrence prevention, and vein wall remodeling. In addition, we also provide suggestions on EPCs as a therapeutic choice for thrombus resolution.
Keywords: Endothelial progenitor cells; Revascularization; Thrombosis.
Copyright © 2015 Elsevier Inc. All rights reserved.
Similar articles
- MiR-150 promotes angiogensis and proliferation of endothelial progenitor cells in deep venous thrombosis by targeting SRCIN1.
Wang W, Zhu X, Du X, Xu A, Yuan X, Zhan Y, Liu M, Wang S. Wang W, et al. Microvasc Res. 2019 May;123:35-41. doi: 10.1016/j.mvr.2018.10.003. Epub 2018 Oct 11. Microvasc Res. 2019. PMID: 30315850 - Human cancer cells suppress behaviors of endothelial progenitor cells through miR-21 targeting IL6R.
Wang W, Yuan X, Xu A, Zhu X, Zhan Y, Wang S, Liu M. Wang W, et al. Microvasc Res. 2018 Nov;120:21-28. doi: 10.1016/j.mvr.2018.05.007. Epub 2018 May 17. Microvasc Res. 2018. PMID: 29777792 - Down-regulation of miR-361-5p promotes the viability, migration and tube formation of endothelial progenitor cells via targeting FGF1.
Yang X, Song Y, Sun Y, Wang M, Xiang Y. Yang X, et al. Biosci Rep. 2020 Oct 30;40(10):BSR20200557. doi: 10.1042/BSR20200557. Biosci Rep. 2020. PMID: 32985665 Free PMC article. - Endothelial Repair and Regeneration Following Intimal Injury.
Tesfamariam B. Tesfamariam B. J Cardiovasc Transl Res. 2016 Apr;9(2):91-101. doi: 10.1007/s12265-016-9677-1. Epub 2016 Jan 21. J Cardiovasc Transl Res. 2016. PMID: 26797874 Review. - Endothelial progenitor cells: Are they displaying a function in autoimmune disorders?
Ferrante A, Guggino G, Di Liberto D, Ciccia F, Cipriani P, Balistreri CR, Sireci G, Giacomelli R, Triolo G. Ferrante A, et al. Mech Ageing Dev. 2016 Oct;159:44-48. doi: 10.1016/j.mad.2016.05.001. Epub 2016 May 3. Mech Ageing Dev. 2016. PMID: 27153975 Review.
Cited by
- Serum lncRNA RAMP2-AS1 Served as a Biomarker of Deep Vein Thrombosis Occurrence and Development in Elderly.
Zhang H, Feng Q, Ma Q, Li L, Xing Y. Zhang H, et al. Indian J Hematol Blood Transfus. 2024 Oct;40(4):660-667. doi: 10.1007/s12288-024-01782-2. Epub 2024 May 6. Indian J Hematol Blood Transfus. 2024. PMID: 39469176 - The serum of COVID-19 asymptomatic patients up-regulates proteins related to endothelial dysfunction and viral response in circulating angiogenic cells ex-vivo.
Beltrán-Camacho L, Eslava-Alcón S, Rojas-Torres M, Sánchez-Morillo D, Martinez-Nicolás MP, Martín-Bermejo V, de la Torre IG, Berrocoso E, Moreno JA, Moreno-Luna R, Durán-Ruiz MC. Beltrán-Camacho L, et al. Mol Med. 2022 Apr 9;28(1):40. doi: 10.1186/s10020-022-00465-w. Mol Med. 2022. PMID: 35397534 Free PMC article. - Extracellular vesicles in venous thromboembolism and pulmonary hypertension.
Zhang J, Hu X, Wang T, Xiao R, Zhu L, Ruiz M, Dupuis J, Hu Q. Zhang J, et al. J Nanobiotechnology. 2023 Nov 30;21(1):461. doi: 10.1186/s12951-023-02216-3. J Nanobiotechnology. 2023. PMID: 38037042 Free PMC article. Review. - Reactive Oxygen Species in Venous Thrombosis.
Gutmann C, Siow R, Gwozdz AM, Saha P, Smith A. Gutmann C, et al. Int J Mol Sci. 2020 Mar 11;21(6):1918. doi: 10.3390/ijms21061918. Int J Mol Sci. 2020. PMID: 32168908 Free PMC article. Review. - The Inhibitory Effect of Lysophosphatidylcholine on Proangiogenesis of Human CD34+ Cells Derived Endothelial Progenitor Cells.
Zhao H, He Y. Zhao H, et al. Front Mol Biosci. 2021 Jun 10;8:682367. doi: 10.3389/fmolb.2021.682367. eCollection 2021. Front Mol Biosci. 2021. PMID: 34179086 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical