Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use - PubMed (original) (raw)
Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use
Jayne F Tierney et al. PLoS Med. 2015.
Abstract
Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.
Conflict of interest statement
We have read the journal's policy and have the following potential conflicts. JFT, LS, MC and MR are co-convenors of the Cochrane IPD Methods Group. All authors have been involved in the conduct and publication of IPD meta-analyses, related methodological research and guidance on the IPD approach to systematic review, and receive funding for these activities.
Similar articles
- Comparison of aggregate and individual participant data approaches to meta-analysis of randomised trials: An observational study.
Tierney JF, Fisher DJ, Burdett S, Stewart LA, Parmar MKB. Tierney JF, et al. PLoS Med. 2020 Jan 31;17(1):e1003019. doi: 10.1371/journal.pmed.1003019. eCollection 2020 Jan. PLoS Med. 2020. PMID: 32004320 Free PMC article. - The future of Cochrane Neonatal.
Soll RF, Ovelman C, McGuire W. Soll RF, et al. Early Hum Dev. 2020 Nov;150:105191. doi: 10.1016/j.earlhumdev.2020.105191. Epub 2020 Sep 12. Early Hum Dev. 2020. PMID: 33036834 - Predictors of treatment REsponse to inhaled corticosteroids (ICS) in Chronic Obstructive pulmonary disease: randomised controlled trials individual participant Data re-Evaluation-protocol of the ICS-RECODE individual participant data meta-analysis.
Bate S, Fortescue R, Fullwood C, Sperrin M, Simmonds M, Fally M, Hansel J, Miligkos M, Manohar S, Howlett E, Linnell J, Preston A; ICS-RECODE group; Woodcock AA, Singh D, Stewart L, Vestbo J, Mathioudakis AG. Bate S, et al. BMJ Open. 2025 Mar 5;15(3):e095541. doi: 10.1136/bmjopen-2024-095541. BMJ Open. 2025. PMID: 40044194 Free PMC article. - Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis.
Taylor RS, Walker S, Ciani O, Warren F, Smart NA, Piepoli M, Davos CH. Taylor RS, et al. Health Technol Assess. 2019 May;23(25):1-98. doi: 10.3310/hta23250. Health Technol Assess. 2019. PMID: 31140973 Free PMC article. Review. - Get real in individual participant data (IPD) meta-analysis: a review of the methodology.
Debray TP, Moons KG, van Valkenhoef G, Efthimiou O, Hummel N, Groenwold RH, Reitsma JB; GetReal Methods Review Group. Debray TP, et al. Res Synth Methods. 2015 Dec;6(4):293-309. doi: 10.1002/jrsm.1160. Epub 2015 Aug 19. Res Synth Methods. 2015. PMID: 26287812 Free PMC article. Review.
Cited by
- Methods for Integrating Trials and Non-experimental Data to Examine Treatment Effect Heterogeneity.
Brantner CL, Chang TH, Nguyen TQ, Hong H, Stefano LD, Stuart EA. Brantner CL, et al. Stat Sci. 2023 Nov;38(4):640-654. doi: 10.1214/23-sts890. Epub 2023 Nov 6. Stat Sci. 2023. PMID: 38638306 Free PMC article. - Timing of Decompressive Surgery in Patients With Acute Spinal Cord Injury: Systematic Review Update.
Fehlings MG, Hachem LD, Tetreault LA, Skelly AC, Dettori JR, Brodt ED, Stabler-Morris S, Redick BJ, Evaniew N, Martin AR, Davies B, Farahbakhsh F, Guest JD, Graves D, Korupolu R, McKenna SL, Kwon BK. Fehlings MG, et al. Global Spine J. 2024 Mar;14(3_suppl):38S-57S. doi: 10.1177/21925682231197404. Global Spine J. 2024. PMID: 38526929 Free PMC article. - PROTOCOL: Mass deworming for soil-transmitted helminths and schistosomiasis among pregnant women: a systematic review and individual participant data meta-analysis.
Salam RA, Middleton P, Makrides M, Welch V, Gaffey M, Cousens S, Bhutta Z. Salam RA, et al. Campbell Syst Rev. 2018 Jun 12;14(1):1-22. doi: 10.1002/CL2.207. eCollection 2018. Campbell Syst Rev. 2018. PMID: 37131393 Free PMC article. No abstract available. - Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials.
Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, O'Connor C, Whellan D, Keteyian SJ, Coats A, Davos CH, Dalal HM, Dracup K, Evangelista L, Jolly K, Myers J, McKelvie RS, Nilsson BB, Passino C, Witham MD, Yeh GY, Zwisler AO; ExTraMATCH II Collaboration. Taylor RS, et al. Eur J Heart Fail. 2018 Dec;20(12):1735-1743. doi: 10.1002/ejhf.1311. Epub 2018 Sep 26. Eur J Heart Fail. 2018. PMID: 30255969 Free PMC article. Review. - Adjuvant or early salvage radiotherapy for the treatment of localised and locally advanced prostate cancer: a prospectively planned systematic review and meta-analysis of aggregate data.
Vale CL, Fisher D, Kneebone A, Parker C, Pearse M, Richaud P, Sargos P, Sydes MR, Brawley C, Brihoum M, Brown C, Chabaud S, Cook A, Forcat S, Fraser-Browne C, Latorzeff I, Parmar MKB, Tierney JF; ARTISTIC Meta-analysis Group. Vale CL, et al. Lancet. 2020 Oct 31;396(10260):1422-1431. doi: 10.1016/S0140-6736(20)31952-8. Epub 2020 Sep 28. Lancet. 2020. PMID: 33002431 Free PMC article.
References
- Higgins JPT, Green SJ, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Sons Ltd; 2008.
- Sterne JAC, Egger M, Moher D, on behalf of the Cochrane Bias Methods Group. Addressing reporting biases In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: Wiley & Sons Ltd; 2008. p. 297–333.
- Stewart LA, Clarke MJ, on behalf of the Cochrane Working Party Group on Meta-analysis using Individual Patient Data. Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat Med. 1995;14:2057–79. - PubMed
- Stewart LA, Tierney JF. To IPD or Not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Eval Health Prof. 2002;25(1):76–97. - PubMed
- Stewart LA, Tierney JF, Clarke M, on behalf of the Cochrane Individual Patient Data Meta-analysis Methods Group. Reviews of individual patient data In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: Wiley & Sons Ltd; 2008. p. 547–58.
Publication types
MeSH terms
Grants and funding
- G0801402/MRC_/Medical Research Council/United Kingdom
- G0901530/MRC_/Medical Research Council/United Kingdom
- MC_UU_12023/24/MRC_/Medical Research Council/United Kingdom
- MR/L004933/1/MRC_/Medical Research Council/United Kingdom
LinkOut - more resources
Full Text Sources
Other Literature Sources