Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use - PubMed (original) (raw)
Individual Participant Data (IPD) Meta-analyses of Randomised Controlled Trials: Guidance on Their Use
Jayne F Tierney et al. PLoS Med. 2015.
Abstract
Jayne Tierney and colleagues offer guidance on how to spot a well-designed and well-conducted individual participant data meta-analysis.
Conflict of interest statement
We have read the journal's policy and have the following potential conflicts. JFT, LS, MC and MR are co-convenors of the Cochrane IPD Methods Group. All authors have been involved in the conduct and publication of IPD meta-analyses, related methodological research and guidance on the IPD approach to systematic review, and receive funding for these activities.
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References
- Higgins JPT, Green SJ, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Sons Ltd; 2008.
- Sterne JAC, Egger M, Moher D, on behalf of the Cochrane Bias Methods Group. Addressing reporting biases In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: Wiley & Sons Ltd; 2008. p. 297–333.
- Stewart LA, Clarke MJ, on behalf of the Cochrane Working Party Group on Meta-analysis using Individual Patient Data. Practical methodology of meta-analyses (overviews) using updated individual patient data. Stat Med. 1995;14:2057–79. - PubMed
- Stewart LA, Tierney JF. To IPD or Not to IPD? Advantages and disadvantages of systematic reviews using individual patient data. Eval Health Prof. 2002;25(1):76–97. - PubMed
- Stewart LA, Tierney JF, Clarke M, on behalf of the Cochrane Individual Patient Data Meta-analysis Methods Group. Reviews of individual patient data In: Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: Wiley & Sons Ltd; 2008. p. 547–58.
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