One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice - PubMed (original) (raw)
. 2015 Sep 4;464(4):1157-1162.
doi: 10.1016/j.bbrc.2015.07.097. Epub 2015 Jul 21.
Affiliations
- PMID: 26208455
- DOI: 10.1016/j.bbrc.2015.07.097
Free article
One-day high-fat diet induces inflammation in the nodose ganglion and hypothalamus of mice
T M Zaved Waise et al. Biochem Biophys Res Commun. 2015.
Free article
Abstract
A high-fat diet (HFD) induces inflammation in systemic organs including the hypothalamus, resulting in obesity and diabetes. The vagus nerve connects the visceral organs and central nervous system, and the gastric-derived orexigenic peptide ghrelin transmits its starvation signals to the hypothalamus via the vagal afferent nerve. Here we investigated the inflammatory response in vagal afferent neurons and the hypothalamus in mice following one day of HFD feeding. This treatment increased the number of macrophages/microglia in the nodose ganglion and hypothalamus. Furthermore, one-day HFD induced expression of Toll-like receptor 4 in the goblet cells of the colon and upregulated mRNA expressions of the proinflammatory biomarkers Emr1, Iba1, Il6, and Tnfα in the nodose ganglion and hypothalamus. Both subcutaneous administration of ghrelin and celiac vagotomy reduced HFD-induced inflammation in these tissues. HFD intake triggered inflammatory responses in the gut, nodose ganglion, and subsequently in the hypothalamus within 24 h. These findings suggest that the vagal afferent nerve may transfer gut-derived inflammatory signals to the hypothalamus via the nodose ganglion, and that ghrelin may protect against HFD-induced inflammation.
Keywords: Ghrelin; High-fat diet; Inflammation; Nodose ganglion; Vagotomy.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
Similar articles
- Diet-induced obesity causes peripheral and central ghrelin resistance by promoting inflammation.
Naznin F, Toshinai K, Waise TM, NamKoong C, Md Moin AS, Sakoda H, Nakazato M. Naznin F, et al. J Endocrinol. 2015 Jul;226(1):81-92. doi: 10.1530/JOE-15-0139. Epub 2015 May 27. J Endocrinol. 2015. PMID: 26016745 Free PMC article. - Canagliflozin, a sodium glucose cotransporter 2 inhibitor, attenuates obesity-induced inflammation in the nodose ganglion, hypothalamus, and skeletal muscle of mice.
Naznin F, Sakoda H, Okada T, Tsubouchi H, Waise TM, Arakawa K, Nakazato M. Naznin F, et al. Eur J Pharmacol. 2017 Jan 5;794:37-44. doi: 10.1016/j.ejphar.2016.11.028. Epub 2016 Nov 19. Eur J Pharmacol. 2017. PMID: 27876617 - High fat diet induced changes in gastric vagal afferent response to adiponectin.
Kentish SJ, Ratcliff K, Li H, Wittert GA, Page AJ. Kentish SJ, et al. Physiol Behav. 2015 Dec 1;152(Pt B):354-62. doi: 10.1016/j.physbeh.2015.06.016. Epub 2015 Jun 12. Physiol Behav. 2015. PMID: 26074203 - The controversial role of the vagus nerve in mediating ghrelin's actions: gut feelings and beyond.
Perelló M, Cornejo MP, De Francesco PN, Fernandez G, Gautron L, Valdivia LS. Perelló M, et al. IBRO Neurosci Rep. 2022 Mar 12;12:228-239. doi: 10.1016/j.ibneur.2022.03.003. eCollection 2022 Jun. IBRO Neurosci Rep. 2022. PMID: 35746965 Free PMC article. Review. - Neurochemistry of the nodose ganglion.
Zhuo H, Ichikawa H, Helke CJ. Zhuo H, et al. Prog Neurobiol. 1997 Jun;52(2):79-107. doi: 10.1016/s0301-0082(97)00003-8. Prog Neurobiol. 1997. PMID: 9185234 Review.
Cited by
- Moderate-intensity aerobic exercise enhanced dopamine signaling in diet-induced obese female mice without preventing body weight gain.
Emmons HA, Fordahl SC. Emmons HA, et al. Neuroscience. 2024 Sep 13;555:1-10. doi: 10.1016/j.neuroscience.2024.07.020. Epub 2024 Jul 19. Neuroscience. 2024. PMID: 39032807 - A novel fatty acid analogue triggers CD36-GPR120 interaction and exerts anti-inflammatory action in endotoxemia.
Boutanquoi PM, Khan AS, Cabeza L, Jantzen L, Gautier T, Yesylevskyy S, Ramseyer C, Masson D, Van Waes V, Hichami A, Khan NA. Boutanquoi PM, et al. Cell Mol Life Sci. 2024 Apr 10;81(1):176. doi: 10.1007/s00018-024-05207-1. Cell Mol Life Sci. 2024. PMID: 38598021 Free PMC article. - Dietary linoleic acid supplementation protects against obesity-induced microglial reactivity in mice.
Jantzen L, Dumontoy S, Ramadan B, Houdayer C, Haffen E, Hichami A, Khan NA, Van Waes V, Cabeza L. Jantzen L, et al. Sci Rep. 2024 Mar 19;14(1):6644. doi: 10.1038/s41598-024-56959-6. Sci Rep. 2024. PMID: 38503857 Free PMC article. - Bariatric Surgery and Gut-Brain-Axis Driven Alterations in Cognition and Inflammation.
Custers E, Franco A, Kiliaan AJ. Custers E, et al. J Inflamm Res. 2023 Nov 22;16:5495-5514. doi: 10.2147/JIR.S437156. eCollection 2023. J Inflamm Res. 2023. PMID: 38026245 Free PMC article. Review. - Microglia in Central Control of Metabolism.
Kim JD, Copperi F, Diano S. Kim JD, et al. Physiology (Bethesda). 2024 Jan 1;39(1):0. doi: 10.1152/physiol.00021.2023. Epub 2023 Nov 14. Physiology (Bethesda). 2024. PMID: 37962895 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical