Potential protective properties of flax lignan secoisolariciresinol diglucoside - PubMed (original) (raw)

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Potential protective properties of flax lignan secoisolariciresinol diglucoside

Muhammad Imran et al. Nutr J. 2015.

Abstract

Lignans are a group of phytonutrients which are widely distributed in the plant kingdom. Flaxseed is the richest source of providing lignan precursor such as secoisolariciresinol diglucoside (SDG). This article reviews the studies relevant to experimental models in animals and humans demonstrating the possible nutraceutical actions of SDG to prevent and alleviate lifestyle-related diseases. A local and international web-based literature review for this project was carried out to provide information relating to the study. The major key word "SDG" was selected to gather information using the electronic databases pertaining to the current state of flaxseed lignans composition, bioactive compounds, metabolism and to find out their role in terms of chemopreventive action. The extraction methods vary from simple to complex depending on separation, fractionation, identification and detection of the analytes. The majority of studies demonstrate that SDG interferes with the development of different types of diseases like cardiovascular, diabetic, lupus nephritis, bone, kidney, menopause, reproduction, mental stress, immunity, atherosclerosis, hemopoietic, liver necrosis and urinary disorders due to its various biological properties including anti-inflammatory, antioxidant, antimutagenic, antimicrobial, antiobesity, antihypolipidemic and neuroprotective effects. Moreover, SDG has a defending mediator against various cancers by modulating multiple cell signaling pathways. As discussed in this review, SDG has shown therapeutic potential against a number of human diseases and can be recommended for discerning consumers.

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References

    1. Bernacchia R, Preti R, Vinci G. Chemical composition and health benefits of flaxseed. Austin J Nutri Food Sci. 2014;2:1045.
    1. Schmidt TJ, Klaes M, Sendker J. Lignans in seeds of Linum species. Phytochem. 2012;82:89–99. doi: 10.1016/j.phytochem.2012.07.004. - DOI - PubMed
    1. Setchell KD, Brown NM, Zimmer-Nechemias L, Wolfe B, Jha P, Heubi JE. Metabolism of secoisolariciresinol-diglycoside the dietary precursor to the intestinally derived lignan enterolactone in humans. Food Funct. 2014;5:491–501. doi: 10.1039/c3fo60402k. - DOI - PMC - PubMed
    1. Herchi W, Arráez-Román D, Trabelsi H, Bouali I, Boukhchina S, Kallel H, et al. Phenolic compounds in flaxseed: a review of their properties and analytical methods. An overview of the last decade. J Oleo Sci. 2014;63:7–14. doi: 10.5650/jos.ess13135. - DOI - PubMed
    1. Hano C, Martin I, Fliniaux O, Legrand B, Gutierrez L, Arroo RR, et al. Pinoresinol-lariciresinol reductase gene expression and secoisolariciresinol diglucoside accumulation in developing flax (Linum usitatissimum) seeds. Planta. 2006;224:1291–301. doi: 10.1007/s00425-006-0308-y. - DOI - PubMed

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