From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches - PubMed (original) (raw)
. 2015 Aug-Sep;338(8-9):613-6.
doi: 10.1016/j.crvi.2015.06.003. Epub 2015 Aug 3.
Affiliations
- PMID: 26251072
- DOI: 10.1016/j.crvi.2015.06.003
Free article
From steroid hormones to depressive states and senile dementias: New mechanistic, therapeutical and predictive approaches
Étienne-Émile Baulieu. C R Biol. 2015 Aug-Sep.
Free article
Abstract
The discovery of "neurosteroids" leads to new descriptions and treatments of neuro-pathological pathologies. 3-β-methoxy-pregnenolone may be used to treat alterations of neuro-traumatisms and cerebral lesions associated with depressive states. Protein FKBP52 is involved in the dysfunction of the tau protein in Alzheimer's disease and senile dementias. In all cases, neuronal microtubules are involved in the mechanism of lesions and their repair.
Keywords: Alzheimer disease; Antidepressant medication; FKBP52 protein; MAP4343; Maladie d’Alzheimer; Microtubules; Médications antidépresseurs; Neurosteroids; Neurostéroïdes; Protéine FKBP52.
Copyright © 2015. Published by Elsevier SAS.
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