Prevalence and Factors Associated with Nonalcoholic Fatty Liver Disease in a Nonobese Korean Population - PubMed (original) (raw)

Prevalence and Factors Associated with Nonalcoholic Fatty Liver Disease in a Nonobese Korean Population

Hyun Chin Cho. Gut Liver. 2016 Jan.

Abstract

Background/aims: Nonalcoholic fatty liver disease (NAFLD) is an emerging problem in Asia, but little is known about the disease in the nonobese population. The aims of this study were to investigate the prevalence of NAFLD and the factors associated with it in a nonobese Korean population and to compare the clinical characteristics of nonobese and obese subjects with NAFLD.

Methods: This cross-sectional study used data from 2,058 subjects who participated in a medical checkup program.

Results: The prevalence of NAFLD was 12.4% (213/1,711) in the nonobese population. A higher body mass index (BMI), higher homeostasis model assessment of insulin resistance (HOMA-IR) values, higher alanine aminotransferase (ALT) levels, triglyceride concentrations ≥150 mg/dL, and hyperuricemia were independently associated with the presence of NAFLD in the nonobese subjects. Compared with the obese subjects with NAFLD, the nonobese subjects with NAFLD were composed of a higher proportion of females and had lower BMIs, smaller waist circumferences, lower HOMA-IR values, and fewer metabolic irregularities.

Conclusions: Higher BMIs, HOMA-IR values, ALT levels, hypertriglyceridemia, and hyperuricemia were associated with NAFLD in the nonobese subjects. Clinicians should be particularly aware of the possibility of NAFLD in nonobese Asian people.

Keywords: Non-alcoholic fatty liver disease; Nonobese population.

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Figures

Fig. 1

Fig. 1

The prevalence of nonalcoholic fatty liver disease (NAFLD) according to the homeostasis model assessment of insulin resistance (HOMA-IR) quartiles. Multivariate analysis using the variables described in Table 4. Q1 (0.03–0.46): reference; Q2 (0.47–0.69): p=0.911, odds ratio (OR), 0.966, 95% confidence interval (CI), 0.525–1.775; Q3 (0.70–1.03): p=0.070, OR, 1.696, 95% CI, 0.957–3.004; Q4 (1.04–5.99): p<0.001, OR, 3.190, 95% CI, 1.818–5.598.

Fig. 2

Fig. 2

The prevalence of nonalcoholic fatty liver disease (NAFLD) according to serum uric acid quartiles. Multivariate analysis using the variables described in Table 4. Q1 (0.5–4.3 mg/dL): reference; Q2 (4.4–5.2 mg/dL): p=0.302, odds ratio (OR), 1.365, 95% confidence interval (CI), 0.756–2.466; Q3 (5.3–6.0 mg/dL): p=0.065, OR, 1.747, 95% CI, 0.966–3.160; Q4 (6.1–8.9 mg/dL): p=0.002, OR, 2.506, 95% CI, 1.405–4.473.

References

    1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002;346:1221–1231. doi: 10.1056/NEJMra011775. - DOI - PubMed
    1. Kojima S, Watanabe N, Numata M, Ogawa T, Matsuzaki S. Increase in the prevalence of fatty liver in Japan over the past 12 years: analysis of clinical background. J Gastroenterol. 2003;38:954–961. doi: 10.1007/s00535-003-1178-8. - DOI - PubMed
    1. Neuschwander-Tetri BA, Caldwell SH. Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology. 2003;37:1202–1219. doi: 10.1053/jhep.2003.50193. - DOI - PubMed
    1. Farrell GC, Chitturi S, Lau GK, Sollano JD Asia-Pacific Working Party on NAFLD. Guidelines for the assessment and management of non-alcoholic fatty liver disease in the Asia-Pacific region: executive summary. J Gastroenterol Hepatol. 2007;22:775–777. doi: 10.1111/j.1440-1746.2007.05002.x. - DOI - PubMed
    1. Das K, Das K, Mukherjee PS, et al. Nonobese population in a developing country has a high prevalence of nonalcoholic fatty liver and significant liver disease. Hepatology. 2010;51:1593–1602. doi: 10.1002/hep.23567. - DOI - PubMed

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