Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study - PubMed (original) (raw)

Observational Study

. 2015 Aug 12;7(8):6739-50.

doi: 10.3390/nu7085306.

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Observational Study

Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study

Justine Chouet et al. Nutrients. 2015.

Abstract

Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. 192 consecutive participants ≥65 years, recruited in the cross-sectional CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i.e., lowest third below 207 µg/day versus the other two thirds combined). Daily dietary phylloquinone intake was estimated from 50-item interviewer-administered food frequency questionnaire. Cognition was assessed with Mini-Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid-stimulating hormone (TSH), vitamin B12, albumin, and estimated glomerular filtration rate were used as confounders. Compared to participants in the lowest third of dietary phylloquinone intake (n = 64), those with higher intake had higher (i.e., better) mean MMSE score (22.0 ± 5.7 versus 19.9 ± 6.2, p = 0.024) and lower (i.e., better) FBRS score (1.5 ± 1.2 versus 1.9 ± 1.3, p = 0.042). In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1.66, p = 0.013) and inversely associated with FBRS score (adjusted β = -0.33, p = 0.037). Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = -0.24, p = 0.001). Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults.

Keywords: behavior; cognition; diet; older adults; vitamin K.

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Figures

Figure 1

Figure 1

Forest plot for the mean difference of neuropsychiatric scores according to the dietary phylloquinone intake. Horizontal lines correspond to the 95% confidence interval (CI). The vertical line corresponds to a mean difference of 0.00, equivalent to no between-group difference. FBRS: Frontotemporal Behavioral Rating Scale; MMSE: Mini-Mental State Examination; *: lowest third of dietary phylloquinone intake below 206.97 µg/day; †: two other thirds combined of dietary phylloquinone intake.

References

    1. Suttie J.W. Vitamin K in Health and Disease. CRC Press; Boca Raton, FL, USA: 2009.
    1. Ferland G. Vitamin K, an emerging nutrient in brain function. Biofactors. 2012;38:151–157. doi: 10.1002/biof.1004. - DOI - PubMed
    1. Ferland G. Vitamin K and the nervous system: An overview of its actions. Adv. Nutr. 2012;3:204–212. doi: 10.3945/an.111.001784. - DOI - PMC - PubMed
    1. Hall J.G., Pauli R.M., Wilson K.M. Maternal and fetal sequelae of anticoagulation during pregnancy. Am. J. Med. 1980;68:122–140. doi: 10.1016/0002-9343(80)90181-3. - DOI - PubMed
    1. Presse N., Belleville S., Gaudreau P., Greenwood C.E., Kergoat M.J., Morais J.A., Payette H., Shatenstein B., Ferland G. Vitamin K status and cognitive function in healthy older adults. Neurobiol. Aging. 2013;34:2777–2783. doi: 10.1016/j.neurobiolaging.2013.05.031. - DOI - PubMed

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