Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication - PubMed (original) (raw)

Multicenter Study

Changes in Metabolic Hormones in Malaysian Young Adults following Helicobacter pylori Eradication

Theresa Wan-Chen Yap et al. PLoS One. 2015.

Abstract

Background: More than half of the world's adults carry Helicobacter pylori. The eradication of H. pylori may affect the regulation of human metabolic hormones. The aim of this study was to evaluate the effect of H. pylori eradication on meal-associated changes in appetite-controlled insulinotropic and digestive hormones, and to assess post-eradication changes in body mass index as part of a currently on-going multicentre ESSAY (Eradication Study in Stable Adults/Youths) study.

Methods: We enrolled 29 H. pylori-positive young adult (18-30 year-old) volunteer subjects to evaluate the effect of H. pylori eradication on meal-associated changes on eight gastrointestinal hormones, using a multiplex bead assay. Changes in body mass index and anthropometric measurements were recorded, pre- and post-eradication therapy.

Results: Pre-prandial active amylin, total peptide YY (PYY) and pancreatic polypeptide (PP) levels were significantly elevated 12 months post-eradication compared with baseline (n = 18; Wilcoxon's signed rank test, p<0.05). Four of the post-prandial gut metabolic hormones levels (GLP-1, total PYY, active amylin, PP) were significantly higher 12 months post-eradication compared to baseline (n = 18; p<0.05). Following H. pylori eradication, the BMI and anthropometric values did not significantly change.

Conclusions: Our study indicates that H. pylori eradication was associated with long-term disturbance in three hormones (active amylin, PP and total PYY) both pre- and post-prandially and one hormone (GLP-1) post-prandially. Longer post-eradication monitoring is needed to investigate the long-term impact of the observed hormonal changes on metabolic homeostasis.

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Conflict of interest statement

Competing Interests: The authors have declared the following interests: BHP in an employee of BP Healthcare. There are no patents, products in development or marketed products to declare. This did not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Figures

Fig 1

Fig 1. Summary of ESSAY Study.

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References

    1. Clyne M, Dolan B, Reeves EP. Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori. FEMS Microbiol Lett. 2007;268(2):135–43. - PubMed
    1. Robinson K, Atherton JC. Helicobacter pylori-induced acquired immunity and immunoregulation In: Sutton P, Mitchell HM, editors. Helicobacter pylori in the 21st century. Wallingford: CABI; 2010. pp. 94–115.
    1. NIH Consensus Conference. Helicobacter pylori in peptic ulcer disease. NIH consensus development panel on Helicobacter pylori in peptic ulcer disease. JAMA. 1994;272(1):65–9. - PubMed
    1. Moodley Y, Linz B, Bond RP, Nieuwoudt M, Soodyall H, Schlebusch CM, et al. Age of the association between Helicobacter pylori and man. PLoS Pathog. 2012;8(5):e1002693 10.1371/journal.ppat.1002693 - DOI - PMC - PubMed
    1. Muller A, Oertli M, Arnold IC. H. pylori exploits and manipulates innate and adaptive immune cell signaling pathways to establish persistent infection. Cell Commun Signal. 2011;9(1):25 10.1186/1478-811X-9-25 - DOI - PMC - PubMed

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Grants and funding

This study was supported by the University of Malaya-Ministry of Education (UM-MOE) High Impact Research (HIR) Grant UM.C/HIR/MOE/13/4 (HIR Account No: H-50001-00-A000029), by the Diane Belfer Program for Human Microbial Ecology, the C and D fund (philanthropic (non-commercial) anonymous donors), and the Knapp Family Fund. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We would like to also declare that one of the authors is employed by a commercial company called BP Healthcare. This commercial affiliation provided support in the form of salaries for author BHP, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of authors are articulated in the "Author contributions" section.

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