Iron deficiency anaemia - PubMed (original) (raw)
Review
. 2016 Feb 27;387(10021):907-16.
doi: 10.1016/S0140-6736(15)60865-0. Epub 2015 Aug 24.
Affiliations
- PMID: 26314490
- DOI: 10.1016/S0140-6736(15)60865-0
Review
Iron deficiency anaemia
Anthony Lopez et al. Lancet. 2016.
Abstract
Anaemia affects roughly a third of the world's population; half the cases are due to iron deficiency. It is a major and global public health problem that affects maternal and child mortality, physical performance, and referral to health-care professionals. Children aged 0-5 years, women of childbearing age, and pregnant women are particularly at risk. Several chronic diseases are frequently associated with iron deficiency anaemia--notably chronic kidney disease, chronic heart failure, cancer, and inflammatory bowel disease. Measurement of serum ferritin, transferrin saturation, serum soluble transferrin receptors, and the serum soluble transferrin receptors-ferritin index are more accurate than classic red cell indices in the diagnosis of iron deficiency anaemia. In addition to the search for and treatment of the cause of iron deficiency, treatment strategies encompass prevention, including food fortification and iron supplementation. Oral iron is usually recommended as first-line therapy, but the most recent intravenous iron formulations, which have been available for nearly a decade, seem to replenish iron stores safely and effectively. Hepcidin has a key role in iron homoeostasis and could be a future diagnostic and therapeutic target. In this Seminar, we discuss the clinical presentation, epidemiology, pathophysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questions for treatment.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Similar articles
- [Current aspects of diagnosis and therapy of iron deficiency anemia in pregnancy].
Breymann C; Anaemia Working Group. Breymann C, et al. Praxis (Bern 1994). 2001 Aug 2;90(31-32):1283-91. Praxis (Bern 1994). 2001. PMID: 11519193 Review. German. - [Review by expert group in the diagnosis and treatment of anemia in pregnant women. Federación Mexicana de Colegios de Obstetricia y Ginecología].
Montoya Romero Jde J, Castelazo Morales E, Valerio Castro E, Velázquez Cornejo G, Nava Muñoz DA, Escárcega Preciado JA, Montoya Cossío J, Pichardo Villalón GM, Maldonado Aragón A, Santana García HR, Fajardo Dueñas S, Mondragón Galindo CG, García Lee T, García A, Hernández de Morán M, Chávez Güitrón LE, Jiménez Gutiérrez C; Federación Mexicana de Colegios de Obstetricia y Ginecología. Montoya Romero Jde J, et al. Ginecol Obstet Mex. 2012 Sep;80(9):563-80. Ginecol Obstet Mex. 2012. PMID: 23243836 Spanish. - Prepartum anaemia: prevention and treatment.
Milman N. Milman N. Ann Hematol. 2008 Dec;87(12):949-59. doi: 10.1007/s00277-008-0518-4. Epub 2008 Jul 19. Ann Hematol. 2008. PMID: 18641987 Review. - The efficacy and safety of current intravenous iron preparations for the management of iron-deficiency anaemia: a review.
Qunibi WY. Qunibi WY. Arzneimittelforschung. 2010;60(6a):399-412. doi: 10.1055/s-0031-1296304. Arzneimittelforschung. 2010. PMID: 20648931 Review. - RAPIDIRON: Reducing Anaemia in Pregnancy in India-a 3-arm, randomized-controlled trial comparing the effectiveness of oral iron with single-dose intravenous iron in the treatment of iron deficiency anaemia in pregnant women and reducing low birth weight deliveries.
Derman RJ, Goudar SS, Thind S, Bhandari S, Aghai Z, Auerbach M, Boelig R, Charantimath US, Frasso R, Ganachari MS, Gaur KL, Georgieff MK, Jaeger F, Yogeshkumar S, Lalakia P, Leiby B, Majumdar M, Mehta A, Mehta S, Mehta S, Mennemeyer ST, Revankar AP, Sharma DK, Short V, Somannavar MS, Wallace D, Shah H, Singh M, Askari S, Bellad MB; RAPIDIRON Trial Group. Derman RJ, et al. Trials. 2021 Sep 23;22(1):649. doi: 10.1186/s13063-021-05549-2. Trials. 2021. PMID: 34556166 Free PMC article. Clinical Trial.
Cited by
- The Critical Role of the Early Evaluation of Iron and Vitamin B12 Deficiency in Pregnancy.
Gοugοutsi V, Pouliakis A, Argyrios T, Tolia M, Nazos NA, Panagopoulos P, Kokoris S. Gοugοutsi V, et al. Cureus. 2024 Aug 23;16(8):e67592. doi: 10.7759/cureus.67592. eCollection 2024 Aug. Cureus. 2024. PMID: 39310455 Free PMC article. - Uncovering the hidden health burden: a systematic review and meta-analysis of iron deficiency anemia among adolescents, and pregnant women in Pakistan.
Mahar B, Shah T, Shaikh K, Shaikh SN, Uqaili AA, Memon KN, Warsi J, Mangi R, Aliyu S, Abbas Q, Shaikh F. Mahar B, et al. J Health Popul Nutr. 2024 Sep 17;43(1):149. doi: 10.1186/s41043-024-00643-y. J Health Popul Nutr. 2024. PMID: 39289759 Free PMC article. Review. - No genetic association between iron deficiency anemia and ischemic stroke and its subtypes: a bidirectional two-sample Mendelian randomization study.
Chen X, Li A, Zhou W, Yao L. Chen X, et al. Front Neurol. 2024 Aug 19;15:1408758. doi: 10.3389/fneur.2024.1408758. eCollection 2024. Front Neurol. 2024. PMID: 39228510 Free PMC article. - Prevalence and Risk Factors of Iron Deficiency and Anemia in Women of Reproductive Age in the Hispanic Community Health Study/Study of Latinos.
Campbell RK, Dewage BG, Cordero C, Maldonado LE, Sotres-Alvarez D, Daviglus ML, Argos M. Campbell RK, et al. Curr Dev Nutr. 2024 Jul 16;8(8):104419. doi: 10.1016/j.cdnut.2024.104419. eCollection 2024 Aug. Curr Dev Nutr. 2024. PMID: 39224140 Free PMC article. - Common Non-Rheumatic Medical Conditions Mimicking Fibromyalgia: A Simple Framework for Differential Diagnosis.
D'Amuri A, Greco S, Pagani M, Presciuttini B, Ciaffi J, Ursini F. D'Amuri A, et al. Diagnostics (Basel). 2024 Aug 13;14(16):1758. doi: 10.3390/diagnostics14161758. Diagnostics (Basel). 2024. PMID: 39202246 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources