Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation - PubMed (original) (raw)
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Regulation of Adult Neurogenesis and Plasticity by (Early) Stress, Glucocorticoids, and Inflammation
Paul J Lucassen et al. Cold Spring Harb Perspect Biol. 2015.
Abstract
Exposure to stress is one of the best-known negative regulators of adult neurogenesis (AN). We discuss changes in neurogenesis in relation to exposure to stress, glucocorticoid hormones, and inflammation, with a particular focus on early development and on lasting effects of stress. Although the effects of acute and mild stress on AN are generally brief and can be quickly overcome, chronic exposure or more severe forms of stress can induce longer lasting reductions in neurogenesis that can, however, in part, be overcome by subsequent exposure to exercise, drugs targeting the stress system, and some antidepressants. Exposure to stress, particularly during the sensitive period of early life, may (re)program brain plasticity, in particular, in the hippocampus. This may increase the risk to develop cognitive or anxiety symptoms, common to brain diseases like dementia and depression in which plasticity changes occur, and a normalization of neurogenesis may be required for a successful treatment response and recovery.
Copyright © 2015 Cold Spring Harbor Laboratory Press; all rights reserved.
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References
- Abrous DN, Koehl M, Le Moal M. 2005. Adult neurogenesis: From precursors to network and physiology. Physiol Rev 85: 523–569. - PubMed
- Aisa B, Tordera R, Lasheras B, Del Río J, Ramírez MJ. 2007. Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32: 256–266. - PubMed
- Alonso R, Griebel G, Pavone G, Stemmelin J, Le Fur G, Soubrié P. 2003. Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression. Mol Psychiatry 9: 278–286. - PubMed
- Anacker C, Pariante CM. 2012. Can adult neurogenesis buffer stress responses and depressive behaviour? Mol Psychiatry 17: 9–10. - PubMed
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