Testing the Effect of Internal Genes Derived from a Wild-Bird-Origin H9N2 Influenza A Virus on the Pathogenicity of an A/H7N9 Virus - PubMed (original) (raw)
. 2015 Sep 22;12(11):1831-41.
doi: 10.1016/j.celrep.2015.08.029. Epub 2015 Sep 3.
Chengmin Wang 2, Jing Luo 2, Yuliang Zhao 2, Yan Wu 3, Lin Chen 1, Na Zhao 1, Meng Li 1, Chao Xing 2, Huimin Liu 2, Hong Zhang 2, Yung-fu Chang 4, Tianxian Li 5, Hua Ding 3, Xiufeng Wan 6, Hongxuan He 7
Affiliations
- PMID: 26344762
- DOI: 10.1016/j.celrep.2015.08.029
Free article
Testing the Effect of Internal Genes Derived from a Wild-Bird-Origin H9N2 Influenza A Virus on the Pathogenicity of an A/H7N9 Virus
Wen Su et al. Cell Rep. 2015.
Free article
Abstract
Since 2013, avian influenza A(H7N9) viruses have diversified into multiple lineages by dynamically reassorting with other viruses, especially H9N2, in Chinese poultry. Despite concerns about the pandemic threat posed by H7N9 viruses, little is known about the biological properties of H7N9 viruses that may recruit internal genes from genetically distinct H9N2 viruses circulating among wild birds. Here, we generated 63 H7N9 reassortants derived from an avian H7N9 and a wild-bird-origin H9N2 virus. Compared with the wild-type parent, 25/63 reassortants had increased pathogenicity in mice. A reassortant containing PB1 of the H9N2 virus was highly lethal to mice and chickens but was not transmissible to guinea pigs by airborne routes; however, three substitutions associated with adaptation to mammals conferred airborne transmission to the virus. The emergence of the H7N9-pandemic reassortant virus highlights that continuous monitoring of H7N9 viruses is needed, especially at the domestic poultry/wild bird interface.
Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.
Similar articles
- Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus.
Pu J, Wang S, Yin Y, Zhang G, Carter RA, Wang J, Xu G, Sun H, Wang M, Wen C, Wei Y, Wang D, Zhu B, Lemmon G, Jiao Y, Duan S, Wang Q, Du Q, Sun M, Bao J, Sun Y, Zhao J, Zhang H, Wu G, Liu J, Webster RG. Pu J, et al. Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):548-53. doi: 10.1073/pnas.1422456112. Epub 2014 Dec 29. Proc Natl Acad Sci U S A. 2015. PMID: 25548189 Free PMC article. - The Origin of Internal Genes Contributes to the Replication and Transmission Fitness of H7N9 Avian Influenza Virus.
James J, Bhat S, Walsh SK, Karunarathna TK, Sadeyen JR, Chang P, Sealy JE, Mahmood S, Mollett BC, Slomka MJ, Brookes SM, Iqbal M. James J, et al. J Virol. 2022 Nov 23;96(22):e0129022. doi: 10.1128/jvi.01290-22. Epub 2022 Nov 7. J Virol. 2022. PMID: 36342296 Free PMC article. - Newly Emergent Highly Pathogenic H5N9 Subtype Avian Influenza A Virus.
Yu Y, Wang X, Jin T, Wang H, Si W, Yang H, Wu J, Yan Y, Liu G, Sang X, Wu X, Gao Y, Xia X, Yu X, Pan J, Gao GF, Zhou J. Yu Y, et al. J Virol. 2015 Sep;89(17):8806-15. doi: 10.1128/JVI.00653-15. Epub 2015 Jun 17. J Virol. 2015. PMID: 26085150 Free PMC article. - Emergence and development of H7N9 influenza viruses in China.
Zhu H, Lam TT, Smith DK, Guan Y. Zhu H, et al. Curr Opin Virol. 2016 Feb;16:106-113. doi: 10.1016/j.coviro.2016.01.020. Epub 2016 Feb 26. Curr Opin Virol. 2016. PMID: 26922715 Review. - H9N2 influenza virus in China: a cause of concern.
Sun Y, Liu J. Sun Y, et al. Protein Cell. 2015 Jan;6(1):18-25. doi: 10.1007/s13238-014-0111-7. Epub 2014 Nov 11. Protein Cell. 2015. PMID: 25384439 Free PMC article. Review.
Cited by
- Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses.
Bahl K, Senn JJ, Yuzhakov O, Bulychev A, Brito LA, Hassett KJ, Laska ME, Smith M, Almarsson Ö, Thompson J, Ribeiro AM, Watson M, Zaks T, Ciaramella G. Bahl K, et al. Mol Ther. 2017 Jun 7;25(6):1316-1327. doi: 10.1016/j.ymthe.2017.03.035. Epub 2017 Apr 27. Mol Ther. 2017. PMID: 28457665 Free PMC article. - Amino Acid Substitution K470R in the Nucleoprotein Increases the Virulence of H5N1 Influenza A Virus in Mammals.
Chen L, Wang C, Luo J, Li M, Liu H, Zhao N, Huang J, Zhu X, Ma G, Yuan G, He H. Chen L, et al. Front Microbiol. 2017 Jul 11;8:1308. doi: 10.3389/fmicb.2017.01308. eCollection 2017. Front Microbiol. 2017. PMID: 28744280 Free PMC article. - Sequence characteristics and phylogenetic analysis of H9N2 subtype avian influenza A viruses detected from poultry and the environment in China, 2018.
Gao X, Wang N, Chen Y, Gu X, Huang Y, Liu Y, Jiang F, Bai J, Qi L, Xin S, Shi Y, Wang C, Liu Y. Gao X, et al. PeerJ. 2021 Dec 20;9:e12512. doi: 10.7717/peerj.12512. eCollection 2021. PeerJ. 2021. PMID: 35036116 Free PMC article. - Differences in Highly Pathogenic H5N6 Avian Influenza Viral Pathogenicity and Inflammatory Response in Chickens and Ducks.
Wang B, Su Q, Luo J, Li M, Wu Q, Chang H, Du J, Huang C, Ma J, Han S, Yuan G, He Y, Guo M, Zhang Q, He H. Wang B, et al. Front Microbiol. 2021 Jan 29;12:593202. doi: 10.3389/fmicb.2021.593202. eCollection 2021. Front Microbiol. 2021. PMID: 33584608 Free PMC article. - Reassortant H5N1 Avian Influenza Virus Bearing PB2 Gene From a 2009 Pandemic H1N1 Exhibits Increased Pathogenicity in Mice.
Lin X, Yu S, Guo K, Sun X, Yi H, Jin M. Lin X, et al. Front Microbiol. 2018 Apr 3;9:631. doi: 10.3389/fmicb.2018.00631. eCollection 2018. Front Microbiol. 2018. PMID: 29666618 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous